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논문 기본 정보

자료유형
학술저널
저자정보
Soo-Hwan Byun (1.Department of Oral and Maxillofacial Surgery Dongtan Sacred Heart Hospital Hallym University Medi) Kang-Min Ahn (University of Ulsan Asan Medical Cente)
저널정보
대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제43권
발행연도
2021.1
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1 - 7 (7page)

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AbstractBackground: During maxillofacial trauma or oral cancer surgery, peripheral nerve might be damaged by tractioninjury. The purpose of this study was to evaluate functional and histomorphometric changes after traction nerveinjury in the sciatic nerve of a rat model. Methods: A total of 24 Sprague-Dawley rats were equally divided into three groups: unstretched (sham/control,group A), stretched with 0.7N (group B) and 1.5N (group C). Traction injury was performed for 10 min in B and Cgroups. Functional recovery of the sciatic nerve was evaluated by walking track analysis, toe spread test, andpinprick test 2 weeks after injury. The weight of gastrocnemius muscles of both sides was measured to evaluateweight ratio (ipsilateral/contralateral). Total number of axons, axon fiber size, myelin thickness, G-ratio, axonnumber/mm2, diameter of fiber, changes of longitudinal width, and formation of the edema and hematoma wereevaluated by transmission electron microscopy. Results: The sciatic function indexes were ?11.48±4.0, ?15.11±14.84, and ?49.12±35.42 for groups A, B, and C,respectively. Pinprick test showed 3.0, 2.86±0.38, and 1.38±0.52 for A, B, and group C. Muscle weight ratios were0.98±0.13 for group A, 0.70±0.10 for group B, and 0.54±0.05 for group C. There were significant differences in toespread test, pinprick test, and muscle weight ratio between control group and experimental group (p<0.001). In theexperimental group, fiber number, fiber size, G-ratio, fiber number/mm2, myelin thickness, diameter of fiber, andlongitudinal width were decreased with statistical significance. Conclusion: The present study demonstrated that the nerve traction injury in the rat sciatic nerve damaged themotor and sensory function and axonal integrity. The amount of functional nerve damage was proportional to theamount of traction power and dependent on the initial tensile strengths (0.7N and 1.5N).

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