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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제40권 제15호
- 발행연도
- 2018.7
- 수록면
- 1 - 7 (7page)
- DOI
- https://doi.org/10.1186/s40902-018-0153-5
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초록· 키워드
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Background: Bisphosphonate (BP) has the ability to thicken the cortical bone. In addition, it has been reported that the cortical bone thickened by BP has relation to the medication-related osteonecrosis of the jaw (MRONJ).
Therefore, the objective of this article is to analyze the ratio as well as thickness of cortical bone in the mandible using computed tomography (CT) and to evaluate it as the predictive factor of MRONJ.
Methods: The thickness of the cortical bone was measured on a paraxial view of the CT showing the mental foramen in 95 patients: 33 patients with MRONJ (3 males, 30 females), 30 patients taking BP without MRONJ (2 males, 28 females), and 32 controls (9 males, 28 females). Also, the ratios of the cortical bone to the total bone were obtained using the measured values. Based on these results, we compared the difference of mandibular cortical bone ratio between the three groups.
Results: The average cortical bone thickness was measured as 3.81 mm in patients with MRONJ, 3.39 mm in patients taking BP without MRONJ, and 3.23 mm in controls. There was only a significant difference between patients with MRONJ and controls (P < 0.05). On the other hand, the average mandibular cortical bone ratio was measured as 37.9% in patients with MRONJ, 27.9% in patients taking BP without MRONJ, and 23.3% in controls.
There was a significant difference between all groups (P < 0.05).
Conclusion: The mandibular cortical bone ratio is large in order of patients with MRONJ, patients taking BP without MRONJ, and controls. This result suggests that the mandibular cortical bone ratio would be very useful to predict the development of MRONJ.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Chen JS / 2011 / Antiresorptive therapies for osteoporosis: a clinical overview / Nat Rev Endocrinol 8(2):81~91
Russell RG / 2008 / Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy / Osteoporos Int 19(6):733~759
Benford HL / 2001 / Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro / Bone 28(5):465~473
Plotkin LI / 1999 / Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin / J Clin Invest 104(10):1363~1374
Stepan JJ / 2003 / Mechanisms of action of antiresorptive therapies of postmenopausal osteoporosis / Endocr Regul 37(4):225~238
Russell RG / 2008 / Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy / Osteoporos Int 19(6):733~759
Benford HL / 2001 / Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro / Bone 28(5):465~473
Plotkin LI / 1999 / Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin / J Clin Invest 104(10):1363~1374
Stepan JJ / 2003 / Mechanisms of action of antiresorptive therapies of postmenopausal osteoporosis / Endocr Regul 37(4):225~238
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