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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제2호
- 발행연도
- 2017.3
- 수록면
- 153 - 160 (8page)
이용수
초록· 키워드
오류제보하기
In this study, we aim to determine the in vivo effect of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs) on neuropathic pain, using three, principal peripheral neuropathic pain models. Four weeks after hUCBMSC transplantation, we observed significant antinociceptive effect in hUCB-MSC? transplanted rats compared to that in the vehicle-treated control. Spinal cord cells positive for c-fos, CGRP, p-ERK, p-p 38, MMP-9 and MMP 2 were significantly decreased in only CCI model of hUCB-MSCs-grafted rats, while spinal cord cells positive for CGRP, p-ERK and MMP-2 significantly decreased in SNL model of hUCBMSCs- grafted rats and spinal cord cells positive for CGRP and MMP-2 significantly decreased in SNI model of hUCB-MSCs-grafted rats, compared to the control 4 weeks or 8weeks after transplantation (p<0.05). However, cells positive for TIMP-2, an endogenous tissue inhibitor of MMP-2, were significantly increased in SNL and SNI models of hUCB-MSCs-grafted rats. Taken together, subcutaneous injection of hUCBMSCs may have an antinociceptive effect via modulation of pain signaling during pain signal processing within the nervous system, especially for CCI model. Thus, subcutaneous administration of hUCB-MSCs might be beneficial for improving those patients suffering from neuropathic pain by decreasing neuropathic pain activation factors, while increasing neuropathic pain inhibition factor.
목차
등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Dworkin RH / 2002 / An overview of neuropathic pain : syndromes, symptoms, signs, and several mechanisms / Clin J Pain 18:343~349
Bennett GJ / 1988 / A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man / Pain 33:87~107
Kim SH / 1992 / An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat / Pain 50:355~363
Decosterd I / 2000 / Spared nerve injury : an animal model of persistent peripheral neuropathic pain / Pain 87:149~158
Mukhida K / 2007 / Spinal GABAergic transplants attenuate mechanical allodynia in a rat model of neuropathic pain / Stem Cells 25:2874~2885
Bennett GJ / 1988 / A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man / Pain 33:87~107
Kim SH / 1992 / An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat / Pain 50:355~363
Decosterd I / 2000 / Spared nerve injury : an animal model of persistent peripheral neuropathic pain / Pain 87:149~158
Mukhida K / 2007 / Spinal GABAergic transplants attenuate mechanical allodynia in a rat model of neuropathic pain / Stem Cells 25:2874~2885
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