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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 79 - 92 (14page)
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Background and Objective: Failure of vascular smooth muscle apoptosis and inflammatory response in pulmonary arterial hypertension (PAH) is a current research focus. The goals of this study were to determine changes in select gene expressions in monocrotaline (MCT)- induced PAH rat models after human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) transfusion. Materials and Methods: The rats were separated into 3 groups i.e., control group (C group), M group (MCT 60 mg/kg), and U group (hUCB-MSCs transfusion) a week after MCT injection. Results: TUNEL assay showed that the U group had significantly lowered positive apoptotic cells in the lung tissues, as compared with the M group. mRNA of caspase-3, B cell leukemia/lymphoma (Bcl)-2, interleukin (IL)-6, tumor necrosis factor (TNF)-α and vascularendothelial growth factor (VEGF) in the lung tissues were greatly reduced at week 4 in the U group. Immunohistochemical staining of the lung tissues also demonstrated a similar pattern, with the exception of IL-6. The protein expression of caspase-3, Bcl-2 VEGF, IL-6, TNF-α and brain natriuretic peptide in the heart tissues were significantly lower in the U group, as compared with the M group at week2. Furthermore, the protein expression of VEGF, IL-6 and BNP in the heart tissues were significantly lower in the U group at week 4. Collagen content in the heart tissues was significantly lower in the U group, as compared with M group at weeks 2 and 4, respectively. Conclusion: hUCB-MSCs could prevent inflammation, apoptosis and remodeling in MCT-induced PAH rat models
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참고문헌 (30)
참고문헌 신청
Budhiraja R / 2004 / Endothelial dysfunction in pulmonary hypertension / Circulation 109:159~165
Jurasz P / 2010 / Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials / Pharmacol Ther 126:1~8
Jeffery TK / 2002 / Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension / Prog Cardiovasc Dis 45:173~202
Sage E / 2008 / Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery / Respir Res 9:19
Sakao S / 2005 / Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells / FASEB J 19:1178~1180
Jurasz P / 2010 / Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials / Pharmacol Ther 126:1~8
Jeffery TK / 2002 / Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension / Prog Cardiovasc Dis 45:173~202
Sage E / 2008 / Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery / Respir Res 9:19
Sakao S / 2005 / Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells / FASEB J 19:1178~1180
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