지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제4호
- 발행연도
- 2017.7
- 수록면
- 361 - 370 (10page)
이용수
초록· 키워드
오류제보하기
Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM symptoms, we constructed a FM animal model induced by restraint stress with intermittent cold stress. All mice underwent nociceptive assays using electronic von Frey anesthesiometer and Hargreaves equipment. To assess the relationship between tianeptine and expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), and phosphorylated cAMP response element-binding protein (p-CREB), western blotting and immunohistochemistry analyses were performed. In behavioral analysis, nociception tests showed that pain threshold was significantly decreased in the FM group compared to that in the control group. Western blot and immunohistochemical analyses of medial prefrontal cortex (mPFC) and hippocampus showed downregulation of BDNF and p-CREB proteins in the FM group compared to the control group. However, tianeptine recovered these changes in behavioral tests and protein level. Therefore, this FM animal model might be useful for investigating mechanisms linking BDNFCREB pathway and pain. Our results suggest that tianeptine might potentially have therapeutic efficacy for FM.
목차
등록된 정보가 없습니다.
참고문헌 (69)
참고문헌 신청
Clauw DJ / 1995 / Fibromyalgia: more than just a musculoskeletal disease / Am Fam Physician 52:843~851
Rohrbeck J / 2007 / The frequency and characteristics of chronic widespread pain in general practice : a case-control study / Br J Gen Pract 57:109~115
Chrousos GP / 1992 / The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis / JAMA 267:1244~1252
Bardin L / 2009 / Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat : Relevance to human stress-associated painful pathologies / Behav Brain Res 205:360~366
Nishiyori M / 2008 / Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia / Mol Pain 4:52
Rohrbeck J / 2007 / The frequency and characteristics of chronic widespread pain in general practice : a case-control study / Br J Gen Pract 57:109~115
Chrousos GP / 1992 / The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis / JAMA 267:1244~1252
Bardin L / 2009 / Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat : Relevance to human stress-associated painful pathologies / Behav Brain Res 205:360~366
Nishiyori M / 2008 / Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia / Mol Pain 4:52
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