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자료유형
학술저널
저자정보
저널정보
대한통증학회 The Korean Journal of Pain The Korean Journal of Pain 제29권 제4호
발행연도
2016.1
수록면
249 - 254 (6page)

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Background: This study aimed to investigate the effect of strenuous exercise on -endorphine (-END) level in fibromyalgia (FM) patients compared to healthy subjects. Methods: We enrolled 30 FM patients and 15 healthy individuals. All study participants underwent a treadmill exercise test using modified Bruce protocol (M.Bruce). The goal of the test was achieving at least 70% of the predicted maximal heart rate (HRMax). The serum levels of -END were measured before and after the exercise program. Measurements were done while heart rate was at least 70% of its predicted maximum. Results: The mean ± the standard deviation (SD) of exercise duration in the FM and control groups were 24.26 ± 5.29 and 29.06 ± 3.26 minutes, respectively, indicating a shorter time to achieve the goal heart rate in FM patients (P < 0.003). Most FM patients attained 70% HRMax at lower stages (stage 2 and 3) of M.Bruce compared to the control group (70% versus 6.6%, respectively; P < 0.0001). Compared to healthy subjects, FM patients had lower serum -END levels both in baseline and post-exercise status (Mean ± SD: 122.07 ± 28.56 g/ml and 246.55 ± 29.57 g/ml in the control group versus 90.12 ± 20.91 g/ml and 179.80 ± 28.57 g/ml in FM patients, respectively; P < 0.001).Conclusions: We found that FM patients had lower levels of -END in both basal and post-exercise status. Exercise increased serum the -END level in both groups but the average increase in -END in FM patients was significantly lower than in the control group. (Korean J Pain 2016; 29: 249-54)

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