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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제4호
- 발행연도
- 2018.7
- 수록면
- 379 - 389 (11page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.4.379
이용수
초록· 키워드
오류제보하기
A nucleobase adenine is a fundamental component of nucleic acids and adenine nucleotides. Various biological roles of adenine have been discovered. It is not produced from degradation of adenine nucleotides in mammals but produced mainly during polyamine synthesis by dividing cells. Anti-inflammatory roles of adenine have been supported in IgE-mediated allergic reactions, immunological functions of lymphocytes and dextran sodium sulfate-induced colitis. However adenine effects on Toll-like receptor 4 (TLR4)-mediated inflammation by lipopolysaccharide (LPS), a cell wall component of Gram negative bacteria, is not examined. Here we investigated anti-inflammatory roles of adenine in LPS-stimulated immune cells, including a macrophage cell line RAW264.7 and bone marrow derived mast cells (BMMCs) and peritoneal cells in mice. In RAW264.7 cells stimulated with LPS, adenine inhibited production of pro-inflammatory cytokines TNF-α and IL-6 and inflammatory lipid mediators, prostaglandin E2 and leukotriene B4. Adenine impeded signaling pathways eliciting production of these inflammatory mediators. It suppressed IκB phosphorylation, nuclear translocation of nuclear factor κB (NF-κB), phosphorylation of Akt and mitogen activated protein kinases (MAPKs) JNK and ERK. Although adenine raised cellular AMP which could activate AMP-dependent protein kinase (AMPK), the enzyme activity was not enhanced. In BMMCs, adenine inhibited the LPS-induced production of TNF-α, IL-6 and IL-13 and also hindered phosphorylation of NF-κB and Akt. In peritoneal cavity, adenine suppressed the LPS-induced production of TNF-α and IL-6 by peritoneal cells in mice. These results show that adenine attenuates the LPS-induced inflammatory reactions.
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참고문헌 (43)
참고문헌 신청
Kishi T / 1985 / Inhibition by adenine of in vitro immunological functions of normal and adenine phosphoribosyltransferase-deficient human lymphocytes / Immunopharmacology 10:157~162
Hershfield MS / 1977 / Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes / Science 197:1284~1287
Watanabe S / 2003 / Neuroprotective effect of adenine on purkinje cell survival in rat cerebellar primary cultures / J Neurosci Res 74:754~759
Avila MA / 2004 / Methylthioadenosine / Int J Biochem Cell Biol 36:2125~2130
Kamatani N / 1981 / Dependence of adenine production upon polyamine synthesis in cultured human lymphoblasts / Biochim Biophys Acta 675:344~350
Hershfield MS / 1977 / Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes / Science 197:1284~1287
Watanabe S / 2003 / Neuroprotective effect of adenine on purkinje cell survival in rat cerebellar primary cultures / J Neurosci Res 74:754~759
Avila MA / 2004 / Methylthioadenosine / Int J Biochem Cell Biol 36:2125~2130
Kamatani N / 1981 / Dependence of adenine production upon polyamine synthesis in cultured human lymphoblasts / Biochim Biophys Acta 675:344~350
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