지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제4호
- 발행연도
- 2018.7
- 수록면
- 419 - 425 (7page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.4.419
이용수
초록· 키워드
오류제보하기
The superficial dorsal horn of the spinal cord plays an important role in pain transmission and opioid activity. Several studies have demonstrated that opioids modulate pain transmission, and the activation of μ-opioid receptors (MORs) by opioids contributes to analgesic effects in the spinal cord. However, the effect of the activation of MORs on GABAergic interneurons and the contribution to the analgesic effect are much less clear. In this study, using transgenic mice, which allow the identification of GABAergic interneurons, we investigated how the activation of MORs affects the excitability of GABAergic interneurons and synaptic transmission between primary nociceptive afferent and GABAergic interneurons. We found that a selective μ-opioid agonist, [D-Ala2, NMe-Phe4, Gly-ol]-enkephanlin (DAMGO), induced an outward current mediated by K+ channels in GABAergic interneurons. In addition, DAMGO reduced the amplitude of evoked excitatory postsynaptic currents (EPSCs) of GABAergic interneurons which receive monosynaptic inputs from primary nociceptive C fibers. Taken together, we found that DAMGO reduced the excitability of GABAergic interneurons and synaptic transmission between primary nociceptive C fibers and GABAergic interneurons. These results suggest one possibility that suppression of GABAergic interneurons by DMAGO may reduce the inhibition on secondary GABAergic interneurons, which increase the inhibition of the secondary GABAergic interneurons to excitatory neurons in the spinal dorsal horn. In this circumstance, the sum of excitation of the entire spinal network will control the pain transmission.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Basbaum AI / 2009 / Cellular and molecular mechanisms of pain / Cell 139:267~284
Sugiura Y / 1986 / Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin / Science 234:358~361
Kumazawa T / 1978 / Excitation of marginal and substantia gelatinosa neurons in the primate spinal cord: indications of their place in dorsal horn functional organization / J Comp Neurol 177:417~434
Light AR / 1979 / Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers / J Comp Neurol 186:117~131
Zeilhofer HU / 2012 / Fast synaptic inhibition in spinal sensory processing and pain control / Physiol Rev 92:193~235
Sugiura Y / 1986 / Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin / Science 234:358~361
Kumazawa T / 1978 / Excitation of marginal and substantia gelatinosa neurons in the primate spinal cord: indications of their place in dorsal horn functional organization / J Comp Neurol 177:417~434
Light AR / 1979 / Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers / J Comp Neurol 186:117~131
Zeilhofer HU / 2012 / Fast synaptic inhibition in spinal sensory processing and pain control / Physiol Rev 92:193~235
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Immunohistochemical distributions of ClC-2 expression in the GABAergic interneurons following Febrile seizures (FS)
대한체질인류학회 학술대회 연제 초록
2015 .05
-
Disinhibition in pathological pain
대한구강해부학회지
2020 .01
-
The efficacy of GABAergic precursor cells transplantation in alleviating neuropathic pain in animal models: a systematic review and meta-analysis
The Korean Journal of Pain
2022 .01
-
Alteraion of GABAA-α1 receptor positive interneurons in the chronic epilepsy following febrile seizure
대한체질인류학회 학술대회 연제 초록
2017 .06
-
Distribution pattern of abnormal interneuron in the hippocampus following hyperthermic seizure
대한체질인류학회 학술대회 연제 초록
2017 .06
-
GABAergic neuronal development in the embryonic mesencephalon of mice
Korean Journal of Veterinary Research(대한수의학회지)
2020 .02
-
Altered functional efficacy of hippocampal interneuron during epileptogenesis following febrile seizures
대한체질인류학회 학술대회 연제 초록
2017 .06
-
Patients’ perception about opioids and addiction in South Korea
The Korean Journal of Pain
2020 .01
-
만성 비암성 통증 환자의 아편유사제 사용
신경정신의학
2019 .01
-
Guidelines for prescribing opioids for chronic non-cancer pain in Korea
The Korean Journal of Pain
2017 .01
-
Opioid Prescription and Long-Term Survival Outcomes in Adults: A Nationwide Cohort Study in Korea
Journal of Korean Medical Science
2024 .03
-
Drug use evaluation of opioid analgesics in pain management among patients with hematopoietic stem cell transplantation
Blood Research
2020 .01
-
Effect of Opioids on All-cause Mortality and Sustained Opioid Use in Elderly Patients with Hip Fracture: a Korea Nationwide Cohort Study
Journal of Korean Medical Science
2021 .01
-
아편유사제의 안전한 사용
대한의사협회지
2022 .01
-
Effect of Opioids on All-cause Mortality and Opioid Addiction in Total Hip Arthroplasty: a Korea Nationwide Cohort Study
Journal of Korean Medical Science
2021 .01
-
Prevention, diagnosis, and treatment of opioid use disorder under the supervision of opioid stewardship programs: it’s time to act now
The Korean Journal of Pain
2022 .10
-
침술의 마약성 진통제 남용 해결을 위한 미국 의료정책 고찰
대한한의학회지
2020 .06
-
비암성 통증 환자에서 아편 유사제 약물의 만성적 사용 증례 및 가이드라인 제안
중독정신의학
2019 .01
-
Management pathway for emergency department patients in the setting of the opioid epidemic and emergency department overcrowding
Clinical and Experimental Emergency Medicine
2020 .01
-
Opioid-induced hyperalgesia after implantation of intrathecal morphine pump: a case report
Medical Biological Science and Engineering
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0