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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제5호
- 발행연도
- 2018.9
- 수록면
- 547 - 554 (8page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.5.547
이용수
초록· 키워드
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Itching is a common clinical symptom of skin disease that significantly affects a patient’s quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers in skin are involved in the regulation of itching as well as pain. In this study, we investigated whether curcumin, which acts on TRPV1 receptors, affects histamine-induced itching in mice, using behavioral tests and electrophysiological approaches. We found that histamine-induced itching was blocked by topical application of curcumin in a concentration-dependent manner. In ex-vivo recordings, histamine-induced discharges of peripheral nerves were reduced by the application of curcumin, indicating that curcumin acts directly on peripheral nerves. Additionally, curcumin blocked the histamine-induced inward current via activation of TRPV1 (curcumin IC50=523 nM). However, it did not alter chloroquine-induced itching behavior in mice, which is associated with transient receptor potential ankyrin 1 (TRPA1). Taken together, our results suggest that histamine-induced itching can be blocked by topical application of curcumin through the inhibitory action of curcumin on TRPV1 receptors in peripheral nerves.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Aggarwal BB / 2009 / Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases / Int J Biochem Cell Biol 41:40~59
Aggarwal BB / 2009 / Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets / Trends Pharmacol Sci 30:85~94
Kuttan R / 1987 / Turmeric and curcumin as topical agents in cancer therapy / Tumori 73:29~31
Chen HW / 1998 / Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells / Br J Pharmacol 124:1029~1040
Liu JY / 1993 / Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells / Carcinogenesis 14:857~861
Aggarwal BB / 2009 / Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets / Trends Pharmacol Sci 30:85~94
Kuttan R / 1987 / Turmeric and curcumin as topical agents in cancer therapy / Tumori 73:29~31
Chen HW / 1998 / Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells / Br J Pharmacol 124:1029~1040
Liu JY / 1993 / Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells / Carcinogenesis 14:857~861
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