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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 1,269 - 1,284 (16page)
- DOI
- https://doi.org/10.22246/jikm.2021.42.6.1269
이용수
이 논문의 연구 히스토리 (2)
2021
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- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
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초록· 키워드
오류제보하기
Objectives: Phragmitis Rhizoma is the fresh or dried rhizome of Phragmites communis Trin., which has been prescribed in traditional Korean medicine to relieve fever and vomiting and to nourish the body fluids. Recently, the protective effect of Phragmitis Rhizoma extract or its components on myelotoxicity and inflammatory responses have been reported, but no study has yet been conducted on oxidative stress.
Methods: The present study investigated whether an ethanol extract of Phragmitis Rhizoma (PR) could protect against cellular damage induced by oxidative stress in Chang liver cells.
Results: Pretreatment with PR significantly suppressed the hydrogen peroxide (H2O2)-induced reduction of Chang cell viability and generation of reactive oxygen species (ROS), thereby deferring apoptosis. PR also markedly inhibited H2O2-induced comet tail formation and phospho-γH2AX expression, suggesting that PR protected against oxidative stress?mediated DNA damage. PR also effectively prevented the inhibition of ATP synthesis in H2O2-treated Chang cells by inhibiting the loss of mitochondrial membrane potential, indicating that PR maintains energy metabolism through preservation of mitochondrial function while eliminating ROS generated by H2O2. Immunoblotting results indicated that PR attenuated the H2O2-induced downregulation of Bcl-2 and upregulation of Bax expression.
Conclusions: PR protects against oxidative injury in Chang liver cells by regulating energy homeostasis via ROS generation blockade, which is at least partly mediated through inactivation of the mitochondria-mediated apoptosis pathway.
목차
등록된 정보가 없습니다.
참고문헌 (53)
참고문헌 신청
Zhang W / 2014 / Protective effect of SGK1 in rat hippocampal neurons subjected to ischemia reperfusion / Cell Physiol Biochem 34:299~312
Devasagayam TP / 2004 / Free radicals and antioxidants in human health: current status and future prospects / J Assoc Physicians India 52:794~804
Rao KS / 2009 / Free radical induced oxidative damage to DNA: relation to brain aging and neurological disorders / Indian J Biochem Biophys 46(1):9~15
Wang R / 2014 / Resveratrol protects neurons and the myocardium by reducing oxidative stress and ameliorating mitochondria damage in a cerebral ischemia rat model / Cell Physiol Biochem 34:854~864
De I / 2017 / The mitochondrial unfolded protein response: Role in cellular homeostasis and disease / Curr Mol Med 17(9):587~597
Devasagayam TP / 2004 / Free radicals and antioxidants in human health: current status and future prospects / J Assoc Physicians India 52:794~804
Rao KS / 2009 / Free radical induced oxidative damage to DNA: relation to brain aging and neurological disorders / Indian J Biochem Biophys 46(1):9~15
Wang R / 2014 / Resveratrol protects neurons and the myocardium by reducing oxidative stress and ameliorating mitochondria damage in a cerebral ischemia rat model / Cell Physiol Biochem 34:854~864
De I / 2017 / The mitochondrial unfolded protein response: Role in cellular homeostasis and disease / Curr Mol Med 17(9):587~597
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