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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 568 - 575 (8page)
- DOI
- 10.9799/ksfan.2021.34.6.568
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초록· 키워드
오류제보하기
The purpose of this study was to investigate the effects of extract mixture of C. wilfordii and P. umbrosa (IPLUS-CWPU) on bone growth in 4-week old young male SD rats. To confirm the effect of IPLUS-CWPU, we measured the length of bone growth plate, the ratio of proliferative zone to the length of growth plate and the expression level of insulin-like growth factor, IGF-1. The IPLUS-CWPU treatment shows a significant increase of tibial and femoral growth plate and the ratio of proliferative zone in growth plate. Especially, the length increased by 13.9% and 25.3% in the tibia and femur, respectively, in the high-dose group compared to the normal group. Moreover, the expression of IGF-1 gene in liver was upregulated in IPLUS-CWPU treated groups. These results indicated that IPLUS-CWPU administration could increase the proliferative zone of bone growth plate in early developmental stage by upregulation of IGF-1 gene.
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참고문헌 (44)
참고문헌 신청
Abad V / 1999 / Determinants of spatial polarity in the growth plate / Endocrinology 140:958~962
Bachagol D / 2018 / Stimulation of liver IGF-1 expression promotes peak bone mass achievement in growing rats : A study with pomegranate seed oil / J Nutr Biochem 52:18~26
Bienkowski RS / 1995 / An estimate of the upper limit for the rate of adverse cardiac effects in children treated with growth hormone / J Pediatr Endocrinol Metab 8:309
Bikle DD / 2015 / Role of IGF-I signaling in muscle bone interactions / Bone 80:79~88
Canalis E / 1983 / The hormonal and local regulation of bone formation / Endocr Rev 4:62~77
Bachagol D / 2018 / Stimulation of liver IGF-1 expression promotes peak bone mass achievement in growing rats : A study with pomegranate seed oil / J Nutr Biochem 52:18~26
Bienkowski RS / 1995 / An estimate of the upper limit for the rate of adverse cardiac effects in children treated with growth hormone / J Pediatr Endocrinol Metab 8:309
Bikle DD / 2015 / Role of IGF-I signaling in muscle bone interactions / Bone 80:79~88
Canalis E / 1983 / The hormonal and local regulation of bone formation / Endocr Rev 4:62~77
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