지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 102 - 108 (7page)
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초록· 키워드
오류제보하기
Purpose: We investigated the effects of different stimulation frequencies on the inhibition of bladder overactivity by sacral neuromodulation (SNM) in pigs.
Methods: Implant-driven stimulators were used to stimulate the S3 spinal nerve in 13 pigs. Cystometry was performed by infusing normal saline (NS) or acetic acid (AA). SNM (pulse width, 210 μsec) at frequencies ranging from 5 to 50 Hz was conducted at the intensity threshold at which observable perianal and/or tail movement was induced. Multiple cystometrograms were performed to determine the effects of different frequencies on the micturition reflex.
Results: AA-induced bladder overactivity significantly reduced the bladder capacity (BC) to 34.4%±4.7% of the NS control level (354.4±35.9 mL) (P<0.05). During AA infusion, SNM at 5 Hz did not significantly change the BC (48.1%±6.9% of the NS control level) (P>0.05), but SNM at 15, 30, and 50 Hz significantly increased the BC to 54.5%±7.1%, 55.2%±6.5%, and 57.2%±6.1% of the NS control level (P<0.05), respectively. No significant differences were found among the results obtained using frequencies of 15, 30, and 50 Hz (P>0.05).
Conclusions: This study demonstrated that 15 Hz was an appropriate frequency for SNM and that frequencies higher than 15 Hz did not lead to better surgical outcomes.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
D’Souza AO / 2008 / Persistence, adherence, and switch rates among extended-release and immediate-release overactive bladder medications in a regional managed care plan / J Manag Care Pharm 14:291~301
Aboseif S / 2002 / Sacral neuromodulation as an effective treatment for refractory pelvic floor dysfunction / Urology 60:52~56
Fall M / 1991 / Electrical stimulation. A physiologic approach to the treatment of urinary incontinence / Urol Clin North Am 18:393~407
Seif C / 2004 / Findings with bilateral sacral neurostimulation : sixty-two PNETests in patients with neurogenic and idiopathic bladder dysfunctions / Neuromodulation 7:141~145
Chartier-Kastler EJ / 2000 / Long-term results of sacral nerve stimulation(S3)for the treatment of neurogenic refractory urge incontinence related to detrusor hyperreflexia / J Urol 164:1476~1480
Aboseif S / 2002 / Sacral neuromodulation as an effective treatment for refractory pelvic floor dysfunction / Urology 60:52~56
Fall M / 1991 / Electrical stimulation. A physiologic approach to the treatment of urinary incontinence / Urol Clin North Am 18:393~407
Seif C / 2004 / Findings with bilateral sacral neurostimulation : sixty-two PNETests in patients with neurogenic and idiopathic bladder dysfunctions / Neuromodulation 7:141~145
Chartier-Kastler EJ / 2000 / Long-term results of sacral nerve stimulation(S3)for the treatment of neurogenic refractory urge incontinence related to detrusor hyperreflexia / J Urol 164:1476~1480
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