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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 506 - 512 (7page)
- DOI
- https://doi.org/10.4306/pi.2017.14.4.506
이용수
초록· 키워드
오류제보하기
Objective: Hemodialysis patients may have psychological distress and reduced quality of life (QoL) related to chronic physical health problems. Genetic polymorphisms associated with reduced QoL in hemodialysis patients. The aim of this study was to investigate the relationship between genetic polymorphisms and variation in health-related QoL in Korean hemodialysis patients.
Methods: The 36-item Short-Form Health Survey and the Korean Hospital Anxiety and Depression Scale were used to assess health-related QoL and psychological distress, respectively. Twenty hundred and five clinically stable patients from 6 hemodialysis centers have participated with informed consents. Sociodemographic factors, clinical factors, and genotypes of serotonin 1A receptor, brain-derived neurotrophic factors, and glucocorticoid receptor were assessed. Independent t-tests, correlation analyses, multiple regression analyses were performed for statistical analyses.
Results: The serotonin 1A receptor CC genotype group showed significantly higher physical and mental QoL levels than those with the GG/GC genotypes. In the final linear regression analysis, serotonin 1A receptor CC genotype was significantly associated with positive physical and mental QoL levels.
Conclusion: Serotonin 1A receptor polymorphism, as well as age and depression, were significantly associated with mental and physical QoL in hemodialysis patients. Functional activity in the serotonin receptor system may have a modulating effect on health-related QoL in hemodialysis patients.
목차
등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Kimmel PL / 2005 / Depression in end-stage renal disease patients treated with hemodialysis: tools, correlates, outcomes, and needs / Semin Dial 18:91~97
Kimmel PL / 2007 / Depression in end-stage renal disease patients : a critical review / Adv Chronic Kidney Dis 14:328~334
Manns B / 2003 / Quality of life in patients treated with hemodialysis or peritoneal dialysis: what are the important determinants? / Clin Nephrol 60:341~351
Howren MB / 2009 / Associations of depression with Creactive protein, IL-1, and IL-6: a meta-analysis / Psychosom Med 71:171~186
Neumeister A / 2004 / Implications of genetic research on the role of the serotonin in depression : emphasis on the serotonin type 1A receptor and the serotonin transporter / Psychopharmacology(Berl) 174:512~524
Kimmel PL / 2007 / Depression in end-stage renal disease patients : a critical review / Adv Chronic Kidney Dis 14:328~334
Manns B / 2003 / Quality of life in patients treated with hemodialysis or peritoneal dialysis: what are the important determinants? / Clin Nephrol 60:341~351
Howren MB / 2009 / Associations of depression with Creactive protein, IL-1, and IL-6: a meta-analysis / Psychosom Med 71:171~186
Neumeister A / 2004 / Implications of genetic research on the role of the serotonin in depression : emphasis on the serotonin type 1A receptor and the serotonin transporter / Psychopharmacology(Berl) 174:512~524
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