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논문 기본 정보

자료유형
학술저널
저자정보
Meltem Gungor (Sanko University) Ergul Belge Kurutas (Sutcu Imam University) Erkan Oner (Mersin University) Velid Unsal (Mardin Artuklu University) Hatice Altun (Sutcu Imam University) Ali Erdinc Yalin (Mersin University) Serap Yalin (Mersin University) Ozlem Bozkus (Sutcu Imam University) Nilfer Sahin (Sitki Koçman University)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제3호
발행연도
2021.8
수록면
530 - 536 (7page)
DOI
10.9758/cpn.2021.19.3.530

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Objective: Attention deficit hyperactivity disorder (ADHD) is a heterogeneous, highly heritable, a common childhood neurobehavioural disorder resulting from complex gene-gene and gene-environment interactions. The erythropoietin (Epo)/erythropoietin receptors (EpoR) system turned out to have additional important functions in nonhematopoietic tissue. In this study, we aimed to investigate the levels of Epo and and EpoR, and also their diagnostic values in children with ADHD. Methods: A total of 70 children were included in the study, 35 drug-naive patients with ADHD (age: 6?12 years; male/female: 20/15) and 35 healthy controls (age: 6?12 years; male/female: 22/13). Serum Epo and EpoR levels was determined using a commercial sandwich enzyme-linked immunosorbent assay kit. Results: The results indicated that the levels of Epo decreased in patients with ADHD compared to control (p < 0.05). On the other hand, EpoR levels increased in these patients (p < 0.05). Furthermore, the ratio of Epo/EpoR was significantly lower in ADHD patients than controls (p < 0.05). Receiver operator characteristic curve analysis showed high diagnostic performance for Epo and EpoR, areas under curve were 0.980 and 1.000, respectively. Conclusion: This is the first report to investigate the association between serum Epo and EpoR levels in ADHD patients. Our results indicated that Epo may play a role in the etiology of ADHD, and Epo therapy may be beneficial in these disorders if given in addition to the routine treatment of children with ADHD. Furthermore, our results reveal possible diagnostic value of Epo and EpoR.

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