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논문 기본 정보

자료유형
학술저널
저자정보
Vrinda Saxena (Swami Rama Himalayan University) Arghya Pal (All India Institute of Medical Sciences)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제4호
발행연도
2021.11
수록면
589 - 599 (11page)
DOI
10.9758/cpn.2021.19.4.589

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Transcranial direct current stimulation (tDCS) is a form of novel brain stimulating method that has attracted interest owing to its relative inexpensiveness and ease of administration. It has been evaluated in many studies for its effectiveness in improving cognitive symptoms in Alzheimer’s disease (AD). However, our understanding regarding its efficacy and the most effective way of administering tDCS (in terms of lead placement to achieve response and prevent harmful consequences) is still evolving. The current meta-analysis was conducted to resolve the above issues. A search using appropriate keywords and medical subject headings was conducted on PubMed, Scopus and DOAJ database. Studies were analysed on pre-defined inclusion and exclusion criteria. Finally 11 studies were included for quantitative analysis from 1,021 obtained from initial search. All the studies included were methodologically of high quality, though an asymmetrical funnel plot raised the possibility of publication bias. tDCS was found to significantly improve the scores on cognition as compared to sham. Anodal tDCS was found to be significantly beneficial in this regards, whereas cathodal and dual stimulation were not. There were no significant difference in the number of drop-outs and adverse reaction in tDCS and sham group. The quality of evidence that we have reviewed in this study is robust. tDCS, particularly anodal tDCS is an effective treatment modality in AD. It is well tolerated in patients with AD. However, further studies are warranted to probe the role of tDCS in other domains of AD.
#Transcranial direct current stimulation #Alzheimer's disease #Major neurocognitive disorder #Brain stimulation #Meta-analysis.

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참고문헌 (21)

참고문헌 신청
American Psychiatric Association / Diagnostic and statistical manual of mental disorders (DSM-5) google schola Takizawa C / 2015 / Epidemiological and economic burden of Alzheimer’s disease : a systematic literature review of data across Europe and the United States of America / J Alzheimers Dis 43:1271~1284 google schola Budson AE / 2012 / New criteria for Alzheimer disease and mild cognitive impairment : implications for the practicing clinician / Neurologist 18:356~363 google schola Mendiola-Precoma J / 2016 / Therapies for prevention and treatment of Alzheimer’s disease / Biomed Res Int 2016:2589276 google schola Cruz Gonzalez P / 2018 / Can transcranial direct-current stimulation alone or combined with cognitive training be used as a clinical intervention to improve cognitive functioning in persons with mild cognitive impairment and dementia? A systematic review and meta-analysis / Front Hum Neurosci 12:416 google schola

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