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논문 기본 정보

자료유형
학술저널
저자정보
Jaber Alizadehgoradel (Shahid Beheshti University) Saeed Imani (Shahid Beheshti University) Vahid Nejati (Shahid Beheshti University) Marie-Anne Vanderhasselt (Ghent University) Behnam Molaei (Ardabil University) Mohammad Ali Salehinejad (Leibniz Research Centre for Working Environment and Human Factors) Shirin Ahmadi (Mohaghegh-Ardabili University) Mina Taherifard (Mohaghegh-Ardabili University)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제4호
발행연도
2021.11
수록면
653 - 668 (16page)
DOI
10.9758/cpn.2021.19.4.653

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Objective: Transcranial direct current stimulation (tDCS) and mindfulness practices have been proposed as a potential approach to improve executive functions (EFs) and reduce craving in persons with substance use disorders. Based on the neural mechanisms of action of each of these interventions, the combination of both non-pharmacological interventions might have additive effects. In the current study, the effects of tDCS combined with mindfulness-based substance abuse treatment (MBSAT) to improve EFs and reduce craving were investigated in early abstinent methamphetamine abuse. Methods: Eighty (youths aged between 18 and 21) early-abstinent methamphetamine users were randomly assigned to the research groups (tDCS group [n = 20], mindfulness group [n = 20], combined mindfulness-tDCS group [n = 20], and sham group [n = 20]). Active tDCS (1.5 mA,20 min, 12 sessions) or sham tDCS was appliedover the left dorsolateral prefrontal cortex and the MBSAT protocol was used over twelve 50-min sessions. Results: Both in the post-test phase (immediately after the intervention) and follow-up phase (one month after the intervention), performance in most EFs tasks significantly improved in the combination group which received real tDCS ＋ MBSAT, as compared to baseline values and sham stimulation group. Similarly, a significant reduction in craving was observed after intervention inall treatment groups, but not the sham stimulation group. Interestingly, the increase in EFs and the reduction in craving post versus pre tDCS ＋ MBSAT intervention were correlated. Conclusion: Findings from the current study provide initial support for the clinical effectiveness of combination tDCS ＋ MBSAT, possibly influencing cognitive/affective processes.
#Executive functions #Transcranial direct current stimulation #Mindfulness #Substance-related disorders #Youths.

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참고문헌 (71)

참고문헌 신청
Bari A / 2018 / Neuromodulation for substance addiction in human subjects : a review / Neurosci Biobehav Rev 95:33~43 google schola Johnston LD / 2016 / Monitoring the Future national survey results on drug use, 1975-2015 : volume II, college students and adults ages 19-55 / Institute for Social Research, The University of Michigan google schola Volkow ND / 2016 / Neurobiologic advances from the brain disease model of addiction / N Engl J Med 374:363~371 google schola Domínguez-Salas S / 2016 / Impact of general cognition and executive function deficits on addiction treatment outcomes : systematic review and discussion of neurocognitive pathways / Neurosci Biobehav Rev 71:772~801 google schola Pentz MA / 2011 / High calorie, low nutrient food/beverage intake and video gaming in children as potential signals for addictive behavior / Int J Environ Res Public Health 8:4406~4424 google schola

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