Serum Uric Acid Relation for Hearing Threshold Shiftt

Hui-Fang Yang; Tung-Wei Kao; Tao-Chun Peng; Yu-Shan Sun; Fang-Yih Liaw; Chung-Ching Wang; Ju-Ting Hsueh; Wei-Liang Chen

doi:http://dx.doi.org/10.21053/ceo.2016.00346

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자료유형: 학술저널

저자정보: Hui-Fang Yang (Tri-Service General Hospital) Tung-Wei Kao (Tri-Service General Hospital) Tao-Chun Peng (Tri-Service General Hospital) Yu-Shan Sun (Tri-Service General Hospital) Fang-Yih Liaw (Tri-Service General Hospital) Chung-Ching Wang (Tri-Service General Hospital) Ju-Ting Hsueh (Tri-Service General Hospital) Wei-Liang Chen (Tri-Service General Hospital)

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제10권 제2호

발행연도: 2017.6

수록면: 143 - 147 (5page)

DOI: http://dx.doi.org/10.21053/ceo.2016.00346

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Objectives. The effects of serum uric acid (UA) level on a variety of diseases were found from experimental and observational studies via oxidative stress and anti-oxidants. However, research on the association of UA and hearing thresholds is relatively sparse. We investigated this issue in the U.S. general population to evaluate the relationship of serum UA levels and pure tone threshold of hearing. Methods. Forty four thousand eighty four eligible participants aged 20 to 69 years who have serum UA data and received Audiometry Examination Component were enrolled from the National Health and Nutrition Examination Survey 1999?2004. Hearing thresholds (dB) as a pure tone average at low frequencies (0.5, 1, 2 kHz) and at high frequencies (3, 4, 6, and 8 kHz) were computed. Multivariate linear regression models and tertile-based analysis with an extended-model approach for covariates adjustment were used to assess the correlation between serum UA level and hearing thresholds. Results. In the adjusted mode of tertile-based analysis, the regression coefficients elucidated as the change of log-transformed mean hearing thresholds upon comparing participants in the highest tertile of serum UA to those in the lowest tertile were ?0.067 (P=0.023) in high frequency and ?0.058 (P=0.054) in low frequency. After adjusting for multiple pertinent covariates, inverse association between tertiles of serum UA and hearing thresholds remained essentially unchanged. The negative trends between serum UA and hearing thresholds were statistically significant (P for trends <0.05) in tertile-based multiple linear regressions. Conclusion. Individuals with elevated UA levels independently were found to be inversely associated with hearing thresholds for pure tone audiometry in a nationally representative sample of U.S. adults.

#Uric Acid #Hearing #Antioxidants #Neuroprotection

참고문헌 (27)

참고문헌 신청

Hershfield MS / 2010 / Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo / Proc Natl Acad Sci U S A 107(32):14351~14356

Johnson RJ / 2003 / Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? / Hypertension 41(6):1183~1190

Verdecchia P / 2000 / Relation between serum uric acid and risk of cardiovascular disease in essential hypertension: the PIUMA study / Hypertension 36(6):1072~1078

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