Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy

Momotaro Muto; Hirotaka Nakata; Kenichi Ishigaki; Shion Tachibana; Moe Yoshida; Mizue Muto; Nobuyuki Yanagawa; Toshikatsu Okumura

doi:10.5230/jgc.2021.21.e24

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자료유형: 학술저널

저자정보: Momotaro Muto (Engaru Kosei General Hospital) Hirotaka Nakata (Engaru Kosei General Hospital) Kenichi Ishigaki (Engaru Kosei General Hospital) Shion Tachibana (Engaru Kosei General Hospital) Moe Yoshida (Engaru Kosei General Hospital) Mizue Muto (Engaru Kosei General Hospital) Nobuyuki Yanagawa (Engaru Kosei General Hospital) Toshikatsu Okumura (Asahikawa Medical University)

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제21권 제3호

발행연도: 2021.9

수록면: 319 - 324 (6page)

DOI: 10.5230/jgc.2021.21.e24

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The abscopal effect refers to the phenomenon in which local radiotherapy is associated with the regression of metastatic cancer that is distantly located from the irradiated site. Here, we present a case of a patient with advanced gastric cancer and brain metastases who was successfully treated with brain radiotherapy and anti-programmed death-1 (PD-1) therapy-induced abscopal effect. Although anti-PD-1 therapy alone could not prevent disease progression, the metastatic lesions in the brain and also in the abdominal lymph node showed a drastic response after brain radiotherapy and anti-PD-1 therapy. To our knowledge, this is the first reported case of successful treatment of advanced gastric cancer with multiple brain and abdominal lymph node metastases, possibly through anti-PD-1 therapy combined with brain radiotherapy-induced abscopal effect. We suggest that the combination of brain radiotherapy and anti-PD-1 therapy may be considered as a therapeutic option for advanced gastric cancer, especially when there is brain metastasis.

#Gastric cancer #Abscopal effect #Immune checkpoint inhibitor #Brain metastasis #Radiation

참고문헌 (17)

참고문헌 신청

Postow MA / 2012 / Immunologic correlates of the abscopal effect in a patient with melanoma / N Engl J Med 366:925~931

Stamell EF / 2013 / The abscopal effect associated with a systemic anti-melanoma immune response / Int J Radiat Oncol Biol Phys 85:293~295

Hiniker SM / 2012 / A systemic complete response of metastatic melanoma to local radiation and immunotherapy / Transl Oncol 5:404~407

Grimaldi AM / 2014 / Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy / OncoImmunology 3:e28780

Levy A / 2016 / Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab : single centre subset analysis from a phase 1/2 trial / Eur J Cancer 68:156~162

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