지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 887 - 894 (8page)
- DOI
- 10.5009/gnl21001
이용수
초록· 키워드
오류제보하기
Background/Aims: To investigate postpartum hepatic flares and associated factors in highly viremic pregnant patients in the immune tolerance phase who adopted telbivudine (LdT) treatment in the last trimester to reduce vertical transmission of hepatitis B virus.
Methods: Hepatitis B e antigen (HBeAg)-positive, highly viremic pregnant women were recruited for this prospective study. Treatment with LdT was started from 28 weeks of gestation. Virological and biochemical markers were examined before LdT treatment, antepartum and postpartum. Serial blood samples at the same time were collected to detect cytokines and cortisol (COR).
Results: Fifty-six of 153 patients (36.6%) had postpartum hepatic flares, defined as a 2-fold increase in alanine aminotransferase 6 weeks after delivery. Age and the antepartum alanine aminotransferase and postpartum HBeAg levels were independent influencing factors of postpartum hepatic flares. Cytokines showed no regularity during or after pregnancy. Compared with the patients with no postpartum flares, the patients with flares had lower baseline interferon γ and COR levels (p=0.022 and p=0.028) and higher postpartum interferon γ levels (p=0.026).
Conclusions: A high proportion of highly viremic and immune-tolerant pregnant patients treated with LdT in the last trimester had postpartum hepatic flares, which implied that these patients entered the immune clearance phase after delivery. Thus, this may create an appropriate opportunity for re-antiviral therapy.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Cui F / 2013 / Evaluation of policies and practices to prevent mother to child transmission of hepatitis B virus in China: results from China GAVI project final evaluation / Vaccine 31(Suppl 9):J36~J42
Wiseman E / 2009 / Perinatal transmission of hepatitis B virus : an Australian experience / Med J Aust 190:489~492
Xu WM / 2009 / Lamivudine in late pregnancy to prevent perinatal transmission of hepatitis B virus infection : a multicentre, randomized, double-blind, placebocontrolled study / J Viral Hepat 16:94~103
Zou H / 2012 / Virologic factors associated with failure to passive-active immunoprophylaxis in infants born to HBsAg-positive mothers / J Viral Hepat 19:e18
Zhang H / 2014 / Telbivudine or lamivudine use in late pregnancy safely reduces perinatal transmission of hepatitis B virus in real-life practice / Hepatology 60:468~476
Wiseman E / 2009 / Perinatal transmission of hepatitis B virus : an Australian experience / Med J Aust 190:489~492
Xu WM / 2009 / Lamivudine in late pregnancy to prevent perinatal transmission of hepatitis B virus infection : a multicentre, randomized, double-blind, placebocontrolled study / J Viral Hepat 16:94~103
Zou H / 2012 / Virologic factors associated with failure to passive-active immunoprophylaxis in infants born to HBsAg-positive mothers / J Viral Hepat 19:e18
Zhang H / 2014 / Telbivudine or lamivudine use in late pregnancy safely reduces perinatal transmission of hepatitis B virus in real-life practice / Hepatology 60:468~476
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