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자료유형
학술저널
저자정보
장준호 (한림대학교 의과대학 성심병원 정신건강의학교실) 전덕인 (한림대학교) 홍현주 (한림대학교) 정명훈 (한림대학교) 홍나래 (한림대학교)
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대한노인정신의학회 노인정신의학 노인정신의학 제25권 제2호
발행연도
2021.10
수록면
70 - 75 (6page)

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Objective: Neuropsychiatric symptoms are common among patients with major neurocognitive disorder. Antipsychotic medications have been widely used to manage behavioral and psychological symptoms of dementia (BPSD), however efficacy and safety of these agents are conflicting. In this study, we tried to overview the association of antipsychotic medication use and neuropsychiatric symptoms with cognitive decline in patients with Alzheimer’s disease. Methods: We reviewed the medical charts of patients who were diagnosed as major neurocognitive disorder due to Alzheimer’s disease from November 2014 to October 2015. We reviewed whether the subjects had used antipsychotics, and whether patients had neuropsychiatric symptoms. We used linear mixed models to examine the statistical difference between each group. Results: Total of 106 subjects were included in the study. There was no statistically significant difference in cognitive function decline (Korean Version of Mini-Mental State Examination score change) between subjects with or without BPSD (p=0.62), and between subjects with or without antipsychotic medication (p=0.09). Conclusion: There was no evidence that antipsychotic medication and BPSD are associated with more cognitive decline. Findings imply that neuropsychiatric symptoms and cognitive impairment come from different etiologic causes, which highlights the heterogeneity of the disorder. Clinician should decide whether to use antipsychotic medication while carefully considering the effect and side effects of antipsychotic medication throughout the treatment period.

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