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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 379 - 390 (12page)
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Air-classified Brassica juncea L. extract (BJ) was investigated for its anti-obesity effects in C57BL/6J mice fed a high-fat diet (HFD). Mice were divided into two groups: one fed a normal diet (NFD), and the other, an HFD. Mice in the HFD-fed group were subsequently treated with BJ (50, 100, and 200 mg/kg/day) for 8 weeks. Inhibition of HFD-induced obesity by BJ treatment was evaluated by analyzing biochemical parameters and using real-time polymerase chain reaction assays. BJ supplementation significantly decreased the final body weight, adipose tissue size, and epididymal adipose tissue volume in comparison with those in the HFD-induced obese mice (p < 0.05). BJ treatment also decreased serum triglyceride, glucose, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels in obese mice. Furthermore, it attenuated HFDinduced obesity by downregulating C/EBP, PPAR, and SREBP-1c to suppress adipogenesis. Moreover, BJ treatment activated the AMPK pathway, increased ACC phosphorylation, and downstream CPT1 expression in HFD-induced obese mice. These results demonstrate that BJ has anti-obesity effects in vivo, indicating that it is an excellent candidate for developing anti-obesity functional foods.
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참고문헌 (29)
참고문헌 신청
Albu, J. / 1997 / Obesity solutions : report of a meeting / Nutr Rev 55:150~156
백송남 / 2002 / 녹차 섭취가 혈중 지질 성상에 미치는 효과 / Journal of Nutrition and Health 35(8):854~862
Cannon, B. / 2004 / Brownadipose tissue : function and physiological significance / Physiological Rev 84:277~359
Choi, H. / 2007 / Water-soluble extract from Cucubita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model / Biochemical and Biophysical Research Commun 359:419~425
Czaja, A. J / 2014 / Hepatic inflammation and progressive liver fibrosis in chronic liver disease / World J Gastroenterol 20:2515~2532
백송남 / 2002 / 녹차 섭취가 혈중 지질 성상에 미치는 효과 / Journal of Nutrition and Health 35(8):854~862
Cannon, B. / 2004 / Brownadipose tissue : function and physiological significance / Physiological Rev 84:277~359
Choi, H. / 2007 / Water-soluble extract from Cucubita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model / Biochemical and Biophysical Research Commun 359:419~425
Czaja, A. J / 2014 / Hepatic inflammation and progressive liver fibrosis in chronic liver disease / World J Gastroenterol 20:2515~2532
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