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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.11 No.3
- 발행연도
- 2021.8
- 수록면
- 211 - 216 (6page)
- DOI
- https://doi.org/10.1007/s13534-021-00198-5
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초록· 키워드
오류제보하기
A major challenge in treating neurogenerative diseases is delivering drugs across the blood?brain barrier (BBB). In thisreview, we summarized the development of liposome-based drug delivery system with enhanced BBB penetration for effi cientbrain drug delivery. We focused on the liposome-based therapeutics targeting Alzheimer’s disease and Parkinson’s diseasebecause they are most common types of adult chronic neurodegenerative disorders. A variety of liposome with surfacemodifi cation of BBB-targeting ligands have been created to cross the BBB via transcytosis to the therapeutic effi cacy ofAlzheimer’s disease and Parkinson’s disease drugs. Recent advances in liposome are providing alternatives to overcome BBBfor more effi cient therapeutic strategy. To improve the BBB penetration of liposomes, we need to completely understand thepathophysiological changes at the BBB.
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참고문헌 (32)
참고문헌 신청
Gitler AD / 2017 / Neurodegenerative disease : models, mechanisms, and a new hope / Dis Model Mech 10:499~502
Teixeira MI / 2020 / Current insights on lipid nanocarrier-assisted drug delivery in the treatment of neurodegenerative diseases / Eur J Pharm Biopharm 149:192~217
Nussbaum RL / 2003 / Alzheimer’s disease and Parkinson’s disease / N Engl J Med 348:1356~1364
Clark LF / 2016 / The immune system and neuroinflammation as potential sources of blood-based biomarkers for Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease / ACS Chem Neurosci 7:520~527
Saraiva C / 2016 / Nanoparticle-mediated brain drug delivery : overcoming blood–brain barrier to treat neurodegenerative diseases / J Control Release 235:34~47
Teixeira MI / 2020 / Current insights on lipid nanocarrier-assisted drug delivery in the treatment of neurodegenerative diseases / Eur J Pharm Biopharm 149:192~217
Nussbaum RL / 2003 / Alzheimer’s disease and Parkinson’s disease / N Engl J Med 348:1356~1364
Clark LF / 2016 / The immune system and neuroinflammation as potential sources of blood-based biomarkers for Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease / ACS Chem Neurosci 7:520~527
Saraiva C / 2016 / Nanoparticle-mediated brain drug delivery : overcoming blood–brain barrier to treat neurodegenerative diseases / J Control Release 235:34~47
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