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논문 기본 정보

자료유형
학술저널
저자정보
Kim Beomsu (Department of Regulatory Science, Graduated School, Kyung Hee University) Park Byeongmin (Department of Fundamental Pharmaceutical Sciences, Graduated School, Kyung Hee University) You Seungju (Department of Regulatory Science, Graduated School, Kyung Hee University) Jung Suk Han (Department of Fundamental Pharmaceutical Sciences, Graduated School, Kyung Hee University) Lee Soobok (Department of Regulatory Science, Graduated School, Kyung Hee University) Lim Kangseok (Department of Regulatory Science, Graduated School, Kyung Hee University) Choi Yeo Jin (Department of Regulatory Science, Graduated School, Kyung Hee University) Kim Jong-Ho (Department of Regulatory Science, Graduated School, Kyung Hee University) 이상민 (경희대학교)
저널정보
한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation Vol.54 No.4
발행연도
2024.7
수록면
435 - 451 (17page)
DOI
10.1007/s40005-024-00680-z

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Background Drug delivery to the brain is difficult, owing of the presence of a unique structure called the blood–brain barrier (BBB). Thus, strategies that facilitate drug delivery to the brain lesion sites via BBB penetration must be developed to optimally treat brain diseases, and cell membrane-camouflaged nanoparticles (CMCN) have been cited as potential candidates to overcome challenges related to BBB penetration. Area covered This review covers strategies that may facilitate drug delivery to the lesions of brain diseases beyond BBB, specifically focusing on utilization of cell membranes in nanoparticles. We summarized the possible benefits of utilizing cell membranes for delivering nanoparticles and also investigated the differences between cell membrane camouflaged nanoparticles and exosomes. Expert opinion CMCNs possess promising features that can serve as potential candidates for drug delivery vehicles to adequately deliver therapeutic agents to the brain as part of brain disease management. CMCN demonstrates remarkable biocompatibility, as they are designed using biologically derived materials. Moreover, these particles can potentially evade the immune system and prolong circulation time by using cell membrane proteins. The most prominent advantage of CMCN involves mimicking characteristics of cells that can penetrate into the brain. We believe that further research on CMCN will help develop a novel drug delivery platform that can improve brain disease management in the near future.

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