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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 149 - 160 (12page)
- DOI
- 10.4285/kjt.21.0014
이용수
초록· 키워드
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Background: We investigated whether the development of delayed graft function (DGF) in pre-sensitized patients affects the clinical outcomes after deceased-donor kidney transplantation (DDKT).
Methods: The study included 709 kidney transplant recipients (KTRs) from three trans- plant centers. We divided KTRs into four subgroups (highly sensitized DGF, highly sensi- tized non-DGF, low-sensitized DGF, and low-sensitized non-DGF) according to panel re- active antibody level of 50%, or DGF development. We compared post-transplant clinical outcomes among the four subgroups.
Results: Incidence of biopsy-proven acute rejection (BPAR) was higher in two highly sensitized subgroups than in low-sensitized subgroups. It tended to be higher in highly sensitized DGF subgroups than in the highly sensitized non-DGF subgroups. In addition, the highly sensitized DGF subgroup showed the highest risk for BPAR (hazard ratio, 3.051; P=0.005) and independently predicted BPAR. Allograft function was lower in the two DGF subgroups than in the non-DGF subgroup until one month after transplantation, but thereafter it was similar. Death-censored graft loss rates and patient mortality tended to be low when DGF developed, but it did not reach statistical significance.
Conclusions: DGF development in highly sensitized patients increases the risk for BPAR in DDKT compared with patients without DGF, suggesting the need for strict monitoring and management of such cases.
목차
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참고문헌 (40)
참고문헌 신청
Yarlagadda SG / 2008 / Marked variation in the definition and diagnosis of delayed graft function : a systematic review / Nephrol Dial Transplant 23:2995~3003
Irish WD / 2010 / A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation / Am J Transplant 10:2279~2286
Siedlecki A / 2011 / Delayed graft function in the kidney transplant / Am J Transplant 11:2279~2296
Ponticelli C / 2014 / Ischaemia-reperfusion injury : a major protagonist in kidney transplantation / Nephrol Dial Transplant 29:1134~1140
Yarlagadda SG / 2009 / Association between delayed graft function and allograft and patient survival : a systematic review and meta-analysis / Nephrol Dial Transplant 24:1039~1047
Irish WD / 2010 / A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation / Am J Transplant 10:2279~2286
Siedlecki A / 2011 / Delayed graft function in the kidney transplant / Am J Transplant 11:2279~2296
Ponticelli C / 2014 / Ischaemia-reperfusion injury : a major protagonist in kidney transplantation / Nephrol Dial Transplant 29:1134~1140
Yarlagadda SG / 2009 / Association between delayed graft function and allograft and patient survival : a systematic review and meta-analysis / Nephrol Dial Transplant 24:1039~1047
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