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논문 기본 정보

자료유형
학술저널
저자정보
Jungsoo Lee (Department of Neurology Hanyang Univeresity College of Medicine Seoul Korea) Yangmi Park (Department of Neurology Seoul Metropolitan Government Boramae Medical Center) Hyunkee Kim (Department of Neurology Hanyang Univeresity College of Medicine Seoul Korea) Nakhoon Kim (Department of Neurology Hanyang Univeresity College of Medicine Seoul Korea) Wonjae Sung (Department of Neurology Hanyang Univeresity College of Medicine Seoul Korea) Sanggon Lee (Department of Neurology Hanyang Univeresity College of Medicine Seoul Korea) 박진석 (한양대학교)
저널정보
대한임상신경생리학회 Annals of Clinical Neurophysiology Annals of Clinical Neurophysiology 제23권 제2호
발행연도
2021.10
수록면
108 - 116 (9page)
DOI
https://doi.org/10.14253/acn.2021.23.2.108

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Background: Nitrous oxide (N2O) is used in surgery and dentistry for its anesthetic and analgesic effects. However, neurological and psychiatric manifestations of N2O abuse have been increasingly reported among Korean adults. The aim of this study was to demonstrate laboratory findings of N2O abuse in Korean patients. Methods: Patients diagnosed with N2O-induced neuropathy or myelopathy from August 2018 to December 2019 were enrolled. Their clinical presentations and laboratory and imaging findings were analyzed. Results: Sensory changes and limb weakness were present in nine of the enrolled patients. The laboratory findings revealed that seven patients had high homocysteine levels and five had high methylmalonic acid levels in their blood. Nerve conductions studies indicated that axonal neuropathy was present in four cases and longer F-wave and Hoffman’s-reflex latencies were present in two cases. Signal changes in cervical spine imaging occurred in five patients, while two had normal results. Conclusions: Chronic N2O abuse can cause neurological damage or psychiatric problems. Because N2O is illegal for recreational use in Korea, patients tend to hide their history of use. Even though the spinal imaging results were normal, clinicians should consider the possibility of N2O use, and further electrophysiological tests should be applied for precise evaluations.

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