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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 176 - 184 (9page)
- DOI
- 10.4068/cmj.2021.57.3.176
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초록· 키워드
오류제보하기
Histone modifications have been demonstrated to play a significant role in oral squamous cell carcinoma (OSCC) epigenetic regulation. An in-silico analysis of The Cancer Genome Atlas (TCGA) of various histone acetyl transferases (HATs) and histone deacetylases (HDACs) suggested that HATs do not differ between normal and tumor samples whereas HDAC2 and HDAC1 change maximally and marginally respectively between normal and tumor patients with no change being noted in HDAC6 expression. Hence, this investigation was carried out to validate the expression states of HDAC 1, 2 and 6 mRNAs in buccal mucosa and tongue SCC samples in an Indian cohort. Buccal mucosa and tongue squamous cell carcinoma tissues with intact histopathology were processed for RNA isolation followed by cDNA synthesis which was then subjected to q-PCR for HDACs. The average RNA yield of the tongue tissue sample was ∼2 mg/mg of tissue and the A260/280 ratios were between 2.03 and 2.06. The average RNA yield of buccal mucosa tissue sample was ∼1 mg/mg of tissue and the A260/280 ratio were between 2.00 and 2.08. We have demonstrated that HDAC2 was overexpressed in tongue and buccal mucosa samples. Over-expression of HDAC2 imply potential use of HDACi along with standard chemotherapeutic drug in oral cancer treatment.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Warnakulasuriya S / 2009 / Global epidemiology of oral and oropharyngeal cancer / Oral Oncol 45:309~316
Shrestha AD / 2020 / Prevalence and incidence of oral cancer in low- and middle-income countries:a scoping review / Eur J Cancer Care(Engl) 29:e13207
Kusumoto T / 2012 / Comprehensive epigenetic analysis using oral rinse samples : a pilot study / J Oral Maxillofac Surg 70:1486~1494
Zanders E / 2002 / Impact of genomics on medicine / Pharmacogenomics 3:443~446
Audia JE / 2016 / Histone modifications and cancer / Cold Spring Harb Perspect Biol 8:a019521
Shrestha AD / 2020 / Prevalence and incidence of oral cancer in low- and middle-income countries:a scoping review / Eur J Cancer Care(Engl) 29:e13207
Kusumoto T / 2012 / Comprehensive epigenetic analysis using oral rinse samples : a pilot study / J Oral Maxillofac Surg 70:1486~1494
Zanders E / 2002 / Impact of genomics on medicine / Pharmacogenomics 3:443~446
Audia JE / 2016 / Histone modifications and cancer / Cold Spring Harb Perspect Biol 8:a019521
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