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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.2
- 수록면
- 29 - 41 (13page)
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Economically feasible systems for heterologous production of complex secondary metabolites originating from difficult to cultivate species are in demand since Escherichia coli and Saccharomyces cerevisiae are not always suitable for expression of plant and animal genes. An emerging oilseed crop, Camelina sativa, has recently been engineered to produce novel oil profiles, jet fuel precursors, and small molecules of industrial interest.
To establish C. sativa as a system for the production of medicinally relevant compounds, we introduced four genes from Veratrum californicum involved in steroid alkaloid biosynthesis. Together, these four genes produce verazine, the hypothesized precursor to cyclopamine, a medicinally relevant steroid alkaloid whose analogs are currently being tested for cancer therapy in clinical trials. The future supply of this potential cancer treatment is uncertain as V. californicum is slow-growing and not amendable to cultivation.
Moreover, the complex stereochemistry of cyclopamine results in low-yield syntheses. Herein, we successfully engineered C. sativa to synthesize verazine, as well as other V. californicum secondary metabolites, in seed. In addition, we have clarified the stereochemistry of verazine and related V. californicum metabolites.
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참고문헌 (39)
참고문헌 신청
Abdel-Kader MS / 1998 / DNA-damaging steroidal alkaloids from Eclipta alba from the suriname rainforest / J Nat Prod 61:1202~1208
Asomaning J / 2014 / Two-stage thermal conversion of inedible lipid feedstocks to renewable chemicals and fuels / Bioresour Technol 158:55~62
Atanasov AG / 2015 / Discovery and resupply of pharmacologically active plant-derived natural products: A review / Biotechnol Adv 33:1582~1614
Augustin JM / 2015 / Production of mono- and sesquiterpenes in Camelina sativa oilseed / Planta 242:693~708
Augustin MM / 2015 / Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells / Plant J 82:991~1003
Asomaning J / 2014 / Two-stage thermal conversion of inedible lipid feedstocks to renewable chemicals and fuels / Bioresour Technol 158:55~62
Atanasov AG / 2015 / Discovery and resupply of pharmacologically active plant-derived natural products: A review / Biotechnol Adv 33:1582~1614
Augustin JM / 2015 / Production of mono- and sesquiterpenes in Camelina sativa oilseed / Planta 242:693~708
Augustin MM / 2015 / Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells / Plant J 82:991~1003
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