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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제45권 제1호
- 발행연도
- 2015.2
- 수록면
- 79 - 89 (11page)
이용수
초록· 키워드
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The objective of the present study was todesign and develop topical nanoemulsion based TerbinafineHCl (TBH) gel to increase its permeability and efficacyusing rat as an animal model. Nanoemulsions wereprepared by two different techniques viz. high pressurehomogenization and high speed homogenization, the preparednanoemulsions were incorporated into carbomer gelto obtain nanoemulsion based gel, which designated asGel-P and Gel-S respectively. The developed gels wereevaluated for drug content, stability, spreadability, andin vitro permeation using pork skin. The in vivo antifungalefficacy of the developed gels was assessed in albino Wistarrats. The globule size obtained by high pressurehomogenization was less than 2 nm in radius (r.nm) andthat by high speed homogenization was less than 10 r.nm.
In vitro permeation studies revealed that Gel-P(51.19 ± 0.81 %) had higher permeation when comparedto Gel-S (31.72 ± 1.12 %) and marketed cream(19.78 ± 1.01 %) which is essential to treat topical fungaldiseases. In vivo antifungal studies in Wistar rats infectedwith Trichophyton mentagrophytes revealed that topicalapplication of Gel-P and Gel-S cured the infection within3 days compared to 14 days for Marketed Cream (M.C).
This study confirms that the nanoemulsion gels providedgreater permeation followed by cure rates of poorly solubleTBH in animal model and hence these systems could be thepreferred drug carriers for drugs intended for topical use toovercome the permeability and efficacy problems.
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참고문헌 (41)
참고문헌 신청
Amit Kumar Aggarwal / 2014 / Interaction of terbinafine hydrochloride with nicotinamide in solution and solid state / Journal of Pharmaceutical Investigation 44(1):23~32
Alberti I / 2001 / Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum in vivo / Int J Pharm 219:11~19
Anania FA / 2002 / Terbinafine hepatotoxicity resulting in chronic biliary ductopenia and portal fibrosis / Am J Med 112:741~742
Barbero AM / 2009 / Pig and guinea pig skin as surrogates for human in vitro penetration studies : a quantitative review / Toxicol Vitro 23:1~13
Barot BS / 2012 / Microemulsion-based gel of terbinafine for the treatment of onychomycosis : optimization of formulation using D-optimal design / AAPS Pharm Sci Tech 13:184~192
Alberti I / 2001 / Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum in vivo / Int J Pharm 219:11~19
Anania FA / 2002 / Terbinafine hepatotoxicity resulting in chronic biliary ductopenia and portal fibrosis / Am J Med 112:741~742
Barbero AM / 2009 / Pig and guinea pig skin as surrogates for human in vitro penetration studies : a quantitative review / Toxicol Vitro 23:1~13
Barot BS / 2012 / Microemulsion-based gel of terbinafine for the treatment of onychomycosis : optimization of formulation using D-optimal design / AAPS Pharm Sci Tech 13:184~192
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