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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제19권 제4호
- 발행연도
- 2015.7
- 수록면
- 383 - 388 (6page)
이용수
초록· 키워드
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K+ outward currents in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), were investigated using a whole cell patch clamp technique. Littermate heterozygous (+/cir) mice of the same age (postnatal day (P) 0 ?P6) were used as controls. Similar slow rising K+ currents were observed in both genotypes, but their biophysical and pharmacological properties were quite different. The values of Vhalf for activation were significantly different in the heterozygous (+/cir) and homozygous (cir/cir) mice (－8.1±2.2 mV, heterozygous (+/cir) mice (n=7) and －17.2±4.2 mV, homozygous (cir/cir) mice (n=5)). The inactivation curve was expressed by a single first order Boltzmann equation in the homozygous (cir/cir) mice, while it was expressed by a sum of two first order Boltzmann equations in the heterozygous (+/cir) mice. The K+ current of homozygous (cir/cir) mice was more sensitive to TEA in the 1 to 10 mM range, while the 4-AP sensitivities were not different between the two genotypes. Removal of external Ca2+ did not affect the K+ currents in either genotype, indicating that the higher sensitivity of K+ current to TEA in the homozygous (cir/cir) mice was not due to an early expression of Ca2+ activated K+ channels. Our results suggest that the K+ outward current of developing homozygous (cir/cir) mice OHCs is different in both biophysical and pharmacological aspects than that of heterozygous (+/cir) mice.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Marcotti W / 2003 / Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells / J Physiol 548:383~400
Marcotti W / 1999 / Transient expression of an inwardly rectifying potassium conductance in developing inner and outer hair cells along the mouse cochlea / Pflugers Arch 439:113~122
Marcotti W / J Physiol / 1999;520 Pt 3:653~660
Kros CJ / 1998 / Expression of a potassium current in inner hair cells during development of hearing in mice / Nature 394:281~284
Lee JW / 2001 / Circling mouse : possible animal model for deafness / Comp Med 51:550~554
Marcotti W / 1999 / Transient expression of an inwardly rectifying potassium conductance in developing inner and outer hair cells along the mouse cochlea / Pflugers Arch 439:113~122
Marcotti W / J Physiol / 1999;520 Pt 3:653~660
Kros CJ / 1998 / Expression of a potassium current in inner hair cells during development of hearing in mice / Nature 394:281~284
Lee JW / 2001 / Circling mouse : possible animal model for deafness / Comp Med 51:550~554
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