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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제4호
- 발행연도
- 2016.7
- 수록면
- 341 - 346 (6page)
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Membrane-bound HLA-G (mHLA-G) discovery on adipose derived stem cells (ADSCs) as a tolerogenic and immunosuppressive molecule was very important. Many documents have shown that HLA-G expression can be controlled via some hormones such as progesterone (P4) and estradiol (E2). Therefore, this study was designed to evaluate progesterone and estradiol effects on mHLA-G in ADSCs at restricted and combination concentrations. Three independent cell lines were cultured in complete free phenol red DMEM and subcultured to achieve sufficient cells. These cells were treated with P4, E2 and P4 plus E2 at physiologic and pregnancy concentrations for 3 days in cell culture conditions. The HLA-G positive ADSCs was measured via monoclonal anti HLA-G-FITC/ MEMG-09 by means of flow cytometry in nine groups. Data were analyzed by one way ANOVA and Tukey’s post hoc tests. There were no significant values of the mean percentage of HLA-G positive cells in E2-treated and the combination of P4 plus E2-treated ADSCs compared to control cells (p value>0.05) but P4 had a significant increase on mHLA-G in ADSCs (p value<0.05). High P4 concentration increased mHLA-G but E2 and the combination of P4 plus E2 could not change mHLA-G on ADSCs.
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참고문헌 (29)
참고문헌 신청
Wei X / 2013 / Mesenchymal stem cells : a new trend for cell therapy / Acta Pharmacol Sin 34:747~754
Ji Soo Choi / 2012 / Effects of Human Mesenchymal Stem Cell Transplantation Combined with Polymer on Functional Recovery Following Spinal Cord Hemisection in Rats / The Korean Journal of Physiology & Pharmacology 16(6):405~411
Alipour R / 2010 / Phenotypic characterizations and comparison of adult dental stem cells with adipose-derived stem cells / Int J Prev Med 1:164~171
Puissant B / 2005 / Immunomodulatory effect of human adipose tissue-derived adult stem cells : comparison with bone marrow mesenchymal stem cells / Br J Haematol 129:118~129
Shi M / 2011 / Immunomodulatory properties and therapeutic application of mesenchymal stem cells / Clin Exp Immunol 164:1~8
Ji Soo Choi / 2012 / Effects of Human Mesenchymal Stem Cell Transplantation Combined with Polymer on Functional Recovery Following Spinal Cord Hemisection in Rats / The Korean Journal of Physiology & Pharmacology 16(6):405~411
Alipour R / 2010 / Phenotypic characterizations and comparison of adult dental stem cells with adipose-derived stem cells / Int J Prev Med 1:164~171
Puissant B / 2005 / Immunomodulatory effect of human adipose tissue-derived adult stem cells : comparison with bone marrow mesenchymal stem cells / Br J Haematol 129:118~129
Shi M / 2011 / Immunomodulatory properties and therapeutic application of mesenchymal stem cells / Clin Exp Immunol 164:1~8
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