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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 363 - 370 (8page)
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Purpose: Recent studies have suggested that specific single-nucleotide polymorphisms (SNPs) contribute to the clinical features of benign prostatic hyperplasia (BPH). In this study, we investigated the relationships of genetic polymorphisms of the epidermal growth factor (EGF) gene and the epidermal growth factor receptor (EGFR) gene with BPH.
Methods: A total of 218 patients with BPH were enrolled in this study. We evaluated the relationship between eight SNPs in the EGF and EGFR genes and prostate volume, prostate-specific antigen (PSA), and International Prostate Symptom Score of BPH patients. Each SNP was genotyped by direct sequencing. Statistical analysis applying codominant, dominant, recessive, and log-additive models was performed via logistic regression.
Results: The rs11568943 and rs11569017 SNPs in the EGF gene showed significant associations with prostate volume (rs11568943: P=0.038 in the log-additive model, P=0.024 in the allele distribution; rs11569017, P=0.031 in the dominant model, P=0.028 in the log-additive model, P=0.020 in the allele distribution). Additionally, the rs3756261, rs11568943, and rs11569017 SNPs of the EGF gene and the rs2293347 SNP of the EGFR gene were associated with PSA levels (P<0.05 in each model, respectively).
Conclusions: These results suggest that the EGF gene may affect prostate volume. In addition, the EGF and EGFR genes may be associated with PSA levels in patients with BPH.
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참고문헌 (35)
참고문헌 신청
Thapa D / 2015 / Chronic inflammatory mediators enhance prostate cancer development and progression / Biochem Pharmacol 94:53~62
Damodarasamy M / 2015 / Hyaluronan in aged collagen matrix increases prostate epithelial cell proliferation / In Vitro Cell Dev Biol Anim 51:50~58
Soulitzis N / 2006 / Expression analysis of peptide growth factors VEGF, FGF2, TGFB1, EGF and IGF1in prostate cancer and benign prostatic hyperplasia / Int J Oncol 29:305~314
Kim HG / 1999 / EGF receptor signaling in prostate morphogenesis and tumorigenesis / Histol Histopathol 14:1175~1182
Pollan MC / 2003 / Growth factor expression in early stages of benign prostatic hyperplasia upon exposure to sustained delivery of androgens / Biomed Sci Instrum 39:329~334
Damodarasamy M / 2015 / Hyaluronan in aged collagen matrix increases prostate epithelial cell proliferation / In Vitro Cell Dev Biol Anim 51:50~58
Soulitzis N / 2006 / Expression analysis of peptide growth factors VEGF, FGF2, TGFB1, EGF and IGF1in prostate cancer and benign prostatic hyperplasia / Int J Oncol 29:305~314
Kim HG / 1999 / EGF receptor signaling in prostate morphogenesis and tumorigenesis / Histol Histopathol 14:1175~1182
Pollan MC / 2003 / Growth factor expression in early stages of benign prostatic hyperplasia upon exposure to sustained delivery of androgens / Biomed Sci Instrum 39:329~334
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