지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 127 - 133 (7page)
- DOI
- http://dx.doi.org/10.11620/IJOB.2015.40.3.127
이용수
초록· 키워드
오류제보하기
The salivary gland undergoes complex process of growth and differentiation of the branching morphogenesis of ductal system during the prenatal and early postnatal periods which are regulated by various elements in the extracellular matrix.
Extracellular matrix metalloproteinase inducer (EMMPRIN) is a cell adhesion molecule. In the present study, localization and expression of EMMPRIN in development and effects of chorda-lingual denervation and cyclosporine A (CsA) treatment on the EMMPRIN expression were investigated.
Immunohistochemistry, RT-PCR and Western blot were used to determine expression level. Immunohistochemistry revealed that EMMPRIN was localized specifically in the cytoplasm of ductal cells, not acini of the submandibular gland all the postnatal periods. At prenatal day 18, when the formation of ducts was not definite, no immunoreactivity was observed. Both Western blot and RT-PCR analyses revealed that EMMPRIN expression was maintained up to postnatal day 7, decreased after postnatal day 10. The EMMPRIN expression was upregulated by the surgical denervation of the chorda-lingual nerve in the gland as well as by the CsA treatment. The present study suggests that EMMPRIN is a crucial molecule for maintaining physiological functions of the salivary gland.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Denny PC / 1997 / Salivary glands : a paradigm for diversity of gland development / Crit Rev Oral Biol Med 8:51~75
Gresik EW / 1981 / Hormonal regulation of epidermal growth factor and protease in the submandibular gland of the adult mouse / Endocrinology 109:924~929
Chang JC / 1973 / Canalicular blockage / Aust J Ophthamol 1:58~62
Gresik EW / 1980 / Postnatal developmental changes in submandibular glands of rats and mice / J Histochem Cytochem 28:860~870
Yurchenko V / 2001 / CD147 is a signaling receptor for cyclophilin B / Biochem Biophys Res Commun 288:786~788
Gresik EW / 1981 / Hormonal regulation of epidermal growth factor and protease in the submandibular gland of the adult mouse / Endocrinology 109:924~929
Chang JC / 1973 / Canalicular blockage / Aust J Ophthamol 1:58~62
Gresik EW / 1980 / Postnatal developmental changes in submandibular glands of rats and mice / J Histochem Cytochem 28:860~870
Yurchenko V / 2001 / CD147 is a signaling receptor for cyclophilin B / Biochem Biophys Res Commun 288:786~788
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