The Effect of Garlic Derivatives (S-Allylmercaptocysteine, Diallyl Disulfide, and S-Allylcysteine) on Gentamicin Induced Ototoxicity: An Experimental Study

Lokman Uzun; Numan Kokten; Osman Halit Cam; M. Tayyar Kalcioglu; M. Birol Ugur; Gul Ozbilen Acar

doi:http://dx.doi.org/10.21053/ceo.2015.01032

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저자정보: Lokman Uzun (Istanbul Medeniyet University) Numan Kokten (Istanbul Medeniyet University) Osman Halit Cam (Delta Hospital Istanbul) M. Tayyar Kalcioglu (Istanbul Medeniyet University) M. Birol Ugur (Gazi UniversityTurkey) Gul Ozbilen Acar (Istanbul Medeniyet University)

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제4호

발행연도: 2016.12

수록면: 309 - 313 (5page)

DOI: http://dx.doi.org/10.21053/ceo.2015.01032

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Objectives. Gentamicin is a potent aminoglycoside antibiotic. Ototoxicity and nephrotoxicity are the main side effects which restrict the use of gentamicin. Garlic with its intrinsic antioxidant activity may prove beneficial in prevention from ototoxicity. S-allylmercaptocysteine (SAMC), diallyl disulfide (DD), and S-allylcysteine (SAC) are three active compounds found in garlic. In this study, we investigated the effect of SAMC, DD, and SAC on the ototoxicity induced by gentamicin in rats, by using brainstem evoked response audiometry (BERA). Methods. Thirty male Wistar rats with intact Preyer’s reflex initially weighing 220?260 g were randomly assigned to either the gentamicin injection with SAMC treatment group (Genta-w SAMC), DD treatment group (Genta-w DD), SAC treatment group (Genta-w SAC), gentamicin injection without any active compounds (AC) treatment groups (Genta-w/o AC), or control group (n=6 rats each group). Gentamicin was given 120-mg/kg body weight, intraperitoneally once daily for 25 days to subjects in all groups except the control group. SAMC 100-mg/kg, and DD 50-mg/kg body weight were given intragastrically, and SAC 250-mg/kg body weight was given intraperitoneally once daily to subjects in Genta-w SAMC, and Genta-w DD, and Genta-w SAC groups, respectively during the study. After 25 days hearing thresholds were evaluated by using BERA test. Results. The mean amplitude of auditory thresholds (sensation level [SL]) measured by using BERA for the Genta-w SAMC, Genta-w DD, Genta-w SAC, Genta-w/o AC, and control groups were 22±8, 25±5, 30±9, 54±11, and 10±7 dB SL, respectively (mean±SD). The differences between every active compound group (Genta-w SAMC, Genta-w DD, and Genta-w SAC) and Genta-w/o AC were statistically significant (P<0.016). Conclusion. SAMC, DD, and SAC are derivative of garlic seems to attenuate aminoglycoside-induced hearing loss. The effect of SAMC and DD seems to be more prominent than that of SAC.

#Gentamicin #S-allylmercaptocysteine #Diallyl Disulfide #S-allylcysteine #Drug Toxicity

참고문헌 (25)

참고문헌 신청

Schacht J / 1998 / Aminoglycoside ototoxicity : prevention in sight? / Otolaryngol Head Neck Surg 118(5):674~677

Wu WJ. / 2002 / Recent advances in understanding aminoglycoside ototoxicity and its prevention / Audiol Neurootol 7(3):171~174

Oliveira JA. / 2004 / Self-protection against aminoglycoside ototoxicity in guinea pigs / Otolaryngol Head Neck Surg 131(3):271~279

Feldman L. / 2007 / Gentamicin-induced ototoxicity in hemodialysis patients is ameliorated by N-acetylcysteine / Kidney Int 72(3):359~363

Maldonado PD. / 2003 / Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats / Life Sci 73(20):2543~2556

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