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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제3호
- 발행연도
- 2020.1
- 수록면
- 219 - 230 (12page)
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Background Driving the conventional drug in new applications has emerged as a research hotspot for disease treatment. Metformin (MET) is conventionally used for the treatment of type II diabetes. It has also been found to be a versatile molecule with wide biological functions, such as losing weight. anti-aging and anticancer activity. Rational design of nanoparticulate drug delivery systems (nano-DDS) could significantly improve drug delivery efficiency. Recently, a wide range of nano- DDS has been developed to improve the delivery efficacy of MET or to perform as versatile nanoplatforms for efficient drug delivery. Area covered In this review, we outline the emerging trends in advanced nano-DDS of MET, focusing on nano-DDS of MET for diabetes therapy, nano-DDS of MET for anticancer therapeutics, and nano-DDS of MET for other therapeutic aims. Expert opinion Despite the great progression in nano-DDS of MET, there’s still a long way to truly put the conventional drug in new applications. Several important issues should be fully taken into consideration, such the manufacturing cost and economic burdens for patients, the biocompatibility and long-term toxicity of carrier materials, scale-up preparation difficulties, as well as the species gap between human beings and animal models.
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참고문헌 (66)
참고문헌 신청
Abdellatif A / 2016 / Metformin loaded carbopol gel for lowering the intra-abdominal visceral fat / J Bioequiv Availab 8:149~152
Aldea M / 2018 / Metformin delivery using chitosan-capped gold nanoparticles in glioblastoma cell lines / Roman Neurosurg 32(2):230~239
Arafa K / 2018 / Facile development, characterization, and optimization of new metformin-loaded nanocarrier system for efficient colon cancer adjunct therapy / Drug Dev Ind Pharm 44(7):1158~1170
Baker NC / 2018 / A bibliometric review of drug repurposing / Drug Discov Today 23:661~672
Banala VT / 2018 / Synchronized ratiometric codelivery of metformin and topotecan through engineered nanocarrier facilitates in vivo synergistic precision levels at tumor site / Adv Healthc Mater 7(19):1800300
Aldea M / 2018 / Metformin delivery using chitosan-capped gold nanoparticles in glioblastoma cell lines / Roman Neurosurg 32(2):230~239
Arafa K / 2018 / Facile development, characterization, and optimization of new metformin-loaded nanocarrier system for efficient colon cancer adjunct therapy / Drug Dev Ind Pharm 44(7):1158~1170
Baker NC / 2018 / A bibliometric review of drug repurposing / Drug Discov Today 23:661~672
Banala VT / 2018 / Synchronized ratiometric codelivery of metformin and topotecan through engineered nanocarrier facilitates in vivo synergistic precision levels at tumor site / Adv Healthc Mater 7(19):1800300
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