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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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H-bond networks that are formed by polar or charged residues play a critical role in the structure, catalytic activity andstability of proteins. Ketosteroid isomerase (KSI) catalyzes the allylic isomerization of a variety of Δ5-3-ketosteroids by theintramolecular transfer of a proton from the 4β-position to the 6β-position via a dienolate intermediate. An H-bond networkin KSI consists of two catalytic residues (Tyr14 and Asp99), Tyr30, Tyr55, and a water molecule in the highly hydrophobicactive site. In this review, we summarize our current understanding of the role of the H-bond network in the activity,stability, and structure of KSI. Both mutational and structural studies suggest that the H-bond newtork could contributeto the catalysis and stability of KSI through the maintenance of the active-site geometry and the provision of structuralsupport.
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참고문헌 (45)
참고문헌 신청
Bak, D. W. / 2013 / Conserved hydrogen bonding networks of MitoNEET tune Fe-S cluster binding and structural stability / Biochemistry 52:4687~4696
Bordo, D. / 1994 / The role of side-chain hydrogen bonds in the formation and stabilization of secondary structure in soluble proteins / J Mol Biol 243:504~519
Cha, H. J. / 2014 / Three-dimensional structures of a wild-type ketosteroid isomerase and its mutant in solution / Sci Adv Mater 6:2325~2333
차형진 / 2013 / Rescue of Deleterious Mutations by the Compensatory Y30F Mutation in Ketosteroid Isomerase / Molecules and Cells 36(1):39~46
Chakrabarti, S. / 2014 / Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes / Proc Natl Acad Sci USA 111:9048~9053
Bordo, D. / 1994 / The role of side-chain hydrogen bonds in the formation and stabilization of secondary structure in soluble proteins / J Mol Biol 243:504~519
Cha, H. J. / 2014 / Three-dimensional structures of a wild-type ketosteroid isomerase and its mutant in solution / Sci Adv Mater 6:2325~2333
차형진 / 2013 / Rescue of Deleterious Mutations by the Compensatory Y30F Mutation in Ketosteroid Isomerase / Molecules and Cells 36(1):39~46
Chakrabarti, S. / 2014 / Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes / Proc Natl Acad Sci USA 111:9048~9053
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