지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Osteoporosis is a disease that causes the weakening of bone by increasing porosity, which often results in fractures. Osteoporosis treatment measures include the use of Bisphosphonates and estrogen. However, these treatments cannot be used in the long term as these treatments have adverse side effects. Therefore, there is a need to identify better and safer treatment options. For this, 63 plant extracts were screened and among them, six extracts showed high anti-osteoclastic activity with low cytotoxicity. Of these six extracts, three extracts, Cudrania tricuspidata (P371), Ulmus davidiana var. japonica (P401), and Torilis japonica (P411), showed more than 50 percent osteoclast inhibition. While the remaining, Stewartia pseudocamellia extracts I and II (P370, P397) and Cuscuta chinensis (P418), showed moderate or between 40-50 percent osteoclast inhibition. Among all the extracts, Torilis japonica (P411) showed the highest inhibitory action against osteoclast development. Torilis japonica (P411) primary components include Kaempferol, Quercetin, and Luteolin, all proven to inhibit osteoclastogenesis. Stewartia pseudocamellia extracts I and II (P370 and P397) showed moderate or 44% osteoclast inhibition. Stewartia pseudocamellia extract II (P397) enhanced the growth of RAW 264.7 cells by 19%. Torilis japonica (P411) and Stewartia pseudocamellia extract II (P397) suppressed the expression of osteoclast-specific genes in RANKL-induced osteoclastogenesis in RAW 246.7 cells. Torilis japonica (P411) extracts even increased osteoblast-specific RUNX2 gene expression. This results provide that six extracts could be used as a potential treatment option for osteoporosis disease with the extracts of Torilis japonica (P411) and Stewartia pseudocamellia (P397) as an ideal candidates. However, the combination of the extract with higher osteoclastic inhibition and less toxic effects with further analysis should be recommended.
목차
Abstract
INTRODUCTION
RESULTS
DISCUSSION
MATERIALS AND METHODS
CONCLUSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
사상자 에탄올 추출물의 지방세포 분화 억제 효과
생명과학회지
2019 .09
-
The Inactivation of ERK1/2, p38 and NF-kB Is Involved in the Down-Regulation of Osteoclastogenesis and Function by A2B Adenosine Receptor Stimulation
Molecules and Cells
2017 .10
-
Anti-Biofilm Effects of Torilis japonica Ethanol Extracts against Staphylococcus aureus
Journal of Microbiology and Biotechnology
2022 .02
-
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation
Molecules and Cells
2015 .01
-
Antimicrobial agents, outer membrane assembly machine, lipoprotein, lipopolysaccharide, outer membrane β-barrel protein, phospholipid
Journal of Microbiology and Biotechnology
2019 .01
-
Design of a RANK-Mimetic Peptide Inhibitor of Osteoclastogenesis with Enhanced RANKL-Binding Affinity
Molecules and Cells
2016 .04
-
PARK2 Induces Osteoclastogenesis through Activation of the NF-κB Pathway
Molecules and Cells
2022 .10
-
동해안의 석호에서 통발의 분포, 생활사 그리고 생장 특성
생태와 환경
2016 .01
-
Inhibitory Effects of Flavonoids Isolated from the Leaves of Stewartia koreana on Nitric-oxide Production in LPS-stimulated RAW 264.7 Cells
생명과학회지
2018 .05
-
다시마 열수 추출물을 첨가한 고추장 소스의 품질 특성
동아시아식생활학회지
2019 .12
-
갈색거저리 유충 에탄올 추출물이 RANKL에 의해 유도되는 파골세포 분화에 미치는 영향
생명과학회지
2020 .11
-
Inhibitory Effect of RANKL-Induced Osteoclast Differentiation and ROS Generation by Sphaerotylus antarcticus Extract
극지연구소 초록집
2023 .07
-
Interactions between the voracious heterotrophic nanoflagellate Katablepharis japonica and common heterotrophic protists
Algae
2017 .01
-
Lecanorchis japonica var. insularis (Orchidaceae: Vanilloideae), a new variety from Jejudo Island, Korea
식물분류학회지
2020 .12
-
RANKL 유도된 파골세포 분화에 대한 풀무치 에탄올 추출물의 분화 억제 효과
생명과학회지
2019 .10
-
Calcium-Phosphate Crystals Promote RANKL Expression via the Downregulation of DUSP1
Molecules and Cells
2019 .01
-
Phylogenetic analysis of Neottia japonica (Orchidaceae) based on ITS and matK regions
식물분류학회지
2020 .12
-
Synergistic Antimicrobial Effect of Lonicera japonica and Magnolia obovata Extracts and Potential as a Plant-Derived Natural Preservative
Journal of Microbiology and Biotechnology
2018 .01
-
Population genetic analysis reveals secondary contact between Eriocheir sinensis and E. japonica in South Korea
Genes & Genomics
2022 .05
-
Inhibition of Adipogenesis in Mouse 3T3-L1 Pre-adipocytes by an Extract from Sophora japonica Fruit Acting via the AMP-activated Protein Kinase Pathway
한국미생물학회 학술대회논문집
2022 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-24-02-088082664