Experiment of proof-of-principle on prompt gamma-positron emission tomography (PG-PET) system for in-vivo dose distribution verification in proton therapy

천보위; 이현철; 유세환; 서희; 민철희; 최현준

doi:10.1016/j.net.2023.03.004

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자료유형: 학술저널

저자정보: 천보위 (연세대학교) 이현철 (한국원자력통제기술원) 유세환 (연세대학교) 서희 (전북대학교) 민철희 (연세대학교) 최현준 (연세대학교)

저널정보: 한국원자력학회 Nuclear Engineering and Technology Nuclear Engineering and Technology 제55권 제6호

발행연도: 2023.6

수록면: 2,018 - 2,025 (8page)

DOI: 10.1016/j.net.2023.03.004

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In our previous study, we proposed an integrated PG-PET-based imaging method to increase the pre diction accuracy for patient dose distributions. The purpose of the present study is to experimentally validate the feasibility of the PG-PET system. Based on the detector geometry optimized in the previous study, we constructed a dual-head PG-PET system consisting of a 16 16 GAGG scintillator and KETEK SiPM arrays, BaSO4 reflectors, and an 8 8 parallel-hole tungsten collimator. The performance of this system as equipped with a proof of principle, we measured the PG and positron emission (PE) distri butions from a 3 6 10 cm3 PMMA phantom for a 45 MeV proton beam. The measured depth was about 17 mm and the expected depth was 16 mm in the computation simulation under the same con ditions as the measurements. In the comparison result, we can find a 1 mm difference between computation simulation and measurement. In this study, our results show the feasibility of the PG-PET system for in-vivo range verification. However, further study should be followed with the consideration of the typical measurement conditions in the clinic application.

#Proton therapy #Prompt gamma #Positron emission tomography #In vivo dose verification #Experiment #Detector

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주요연구분야 공학 > 재료·에너지공학 > 원자력공학 의약학 > 임상의학 > 방사선과학

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