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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 2,072 - 2,077 (6page)
- DOI
- 10.1016/j.net.2020.02.014
이용수
초록· 키워드
오류제보하기
The purpose of this study was to demonstrate the feasibility of sensing changes in a tumor during boron neutron capture therapy (BNCT) using a Monte Carlo simulation tool. In the simulation, an epi-thermal neutron source and a water phantom including boron uptake regions (BURs) were simulated. Moreover, this simulation also included a detector for positron emission tomography (PET) scanning and an adaptively-designed collimator (ADC) for PET. After the PET scanning of the water phantom, including the 511 keV source in the BUR, the ADC was positioned in the PET's gantry. Single prompt gamma rays were collected through the ADC during neutron irradiation. Then, single prompt gamma ray-based tomography images of different sized tumors were acquired by a four-step process. Both the signal-tonoise ratio (SNR) and tumor size were analyzed from each step image. From this analysis, we identified a decreasing trend of both the SNR and signal intensity as the tumor size decreased, which was confirmed in all images. In conclusion, we confirmed the feasibility of sensing changes in a tumor during BNCT using PET and an ADC through Monte Carlo simulation.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Z. Yong / 2016 / Boron neutron capture therapy for malignant melanoma : first clinical case report in China / Chin. J. Canc. Res 28:634~640
R. F. Barth / 2018 / A realistic appraisal of boron neutron capture therapy as a cancer treatment modality / Canc. Commun 38:36
T. Yamamoto / 2004 / Current clinical results of the Tsukuba BNCT trial / Appl. Radiat. Isot 61:1089~1093
A. H. Soloway / 1967 / Penetration of brain and brain tumor. Ⅶ. Tumor-binding sulfhydryl boron compounds / J. Med. Chem 10:714~717
A. J. Kreiner / 2016 / Present status of accelerator-based BNCT / Rep. Practical Oncol. Radiother 21:95~101
R. F. Barth / 2018 / A realistic appraisal of boron neutron capture therapy as a cancer treatment modality / Canc. Commun 38:36
T. Yamamoto / 2004 / Current clinical results of the Tsukuba BNCT trial / Appl. Radiat. Isot 61:1089~1093
A. H. Soloway / 1967 / Penetration of brain and brain tumor. Ⅶ. Tumor-binding sulfhydryl boron compounds / J. Med. Chem 10:714~717
A. J. Kreiner / 2016 / Present status of accelerator-based BNCT / Rep. Practical Oncol. Radiother 21:95~101
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