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논문 기본 정보

자료유형
학술저널
저자정보
Sanaz Malekian (Department of Midwifery Faculty of Nursing and Midwifery Tabriz University of Medical Sciences Tabriz Iran) Mojgan Mirghafourvand (Social Determinants of Health Research Center Tabriz University of Medical Sciences Tabriz Iran) Farzad Najafipour (Endocrinology Research Center Tabriz University of Medical Sciences Tabriz Iran) Alireza Ostadrahimi (Nutrition Research Center Tabriz University of Medical Sciences Tabriz Iran) Nafiseh Ghassab-Abdollahi (Department of Geriatric Health Faculty of Health Science Student Research Committee Tabriz University of Medical Sciences Tabriz Iran) Azizeh Farshbaf-Khalili (Physical Medicine and Rehabilitation Research Centre Aging Research Institute Tabriz University of Medical Sciences Tabriz Iran)
저널정보
대한가정의학회 Korean Journal of Family Medicine Korean Journal of Family Medicine 제44권 제2호
발행연도
2023.3
수록면
95 - 101 (7page)

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Background: Oxidative stress plays an essential role in bone health among postmenopausal women. This study aimed to compare the oxidative stress biomarkers among postmenopausal women aged 50–65 years with normal bone mineral density, osteopenia, and osteoporosis.Methods: In this observational study, 120 women with normal bone mineral density, 82 with osteopenia, and 86 with osteoporosis were selected based on the densitometry data obtained from the dual-energy X-ray absorptiom-etry method. The serum total antioxidant capacity (TAC), superoxide dismutase (SOD) activity, and malondialde-hyde (MDA) levels were measured using biochemical methods. A binary logistic regression model adjusted for confounders was used to estimate the risk of osteopenia and osteoporosis. The P-value of <0.05 was considered sta-tistically significant.Results: There were significant differences between the three groups in age, menopausal age, body mass index, and education (P<0.05). According to the binary logistic regression model, higher SOD activity and serum TAC lev-els were associated with a lower risk of osteoporosis (adjusted odds ratio [aOR], 0.991; 95% confidence intervals [CI], 0.986 to 0.996; and aOR, 0.373; 95% CI, 0.141 to 0.986, respectively). MDA was a significant risk factor for osteo-penia in postmenopausal women (aOR, 1.702; 95% CI, 1.125 to 2.576).Conclusion: Higher SOD activity and serum TAC levels in the studied postmenopausal women were associated with a significantly lower risk of osteoporosis. Moreover, the risk of osteopenia increased significantly with higher serum MDA levels.

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