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논문 기본 정보

자료유형
학술저널
저자정보
Kim Nak-Hyun (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea.) Choi Yunjung (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea.) Kwon Kyungmi (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea.) Park Jeong Su (Department of Laboratory Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea.) Park Kyoung Un (Department of Laboratory Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea.) Moon Song Mi (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea.) Song Kyoung-Ho (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea.) Kim Eu Suk (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea.) Park Wan Beom (Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul Korea.) Kim Hong Bin (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.38 No.16
발행연도
2023.4
수록면
1 - 12 (12page)
DOI
10.3346/jkms.2023.38.e129

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Background: Alpha-toxin (AT), a major virulence factor of Staphylococcus aureus, is an important immunotherapeutic target to prevent or treat invasive S. aureus infections. Previous studies have suggested that anti-AT antibodies (Abs) may have a protective role against S. aureus bacteremia (SAB), but their function remains unclear. Therefore, we aimed to investigate the association between serum anti-AT Ab levels and clinical outcomes of SAB. Methods: Patients from a prospective SAB cohort at a tertiary-care medical center (n = 51) were enrolled in the study from July 2016 to January 2019. Patients without symptoms or signs of infection were enrolled as controls (n = 100). Blood samples were collected before the onset of SAB and at 2- and 4-weeks post-bacteremia. Anti-AT immunoglobin G (IgG) levels were measured using an enzyme-linked immunosorbent assay. All clinical S. aureus isolates were tested for the presence of hla using polymerase chain reaction. Results: Anti-AT IgG levels in patients with SAB before the onset of bacteremia did not differ significantly from those in non-infectious controls. Pre-bacteremic anti-AT IgG levels tended to be lower in patients with worse clinical outcomes (7-day mortality, persistent bacteremia, metastatic infection, septic shock), although the differences were not statistically significant. Patients who needed intensive care unit care had significantly lower anti-AT IgG levels at 2 weeks post-bacteremia (P = 0.020). Conclusion: The study findings suggest that lower anti-AT Ab responses before and during SAB, reflective of immune dysfunction, are associated with more severe clinical presentations of infection.
#Staphylococcus aureus #Bacteremia #Alpha-Toxin #Anti-Alpha-Toxin Antibody #Antibody Response

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