지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.2
- 수록면
- 32 - 40 (9page)
- DOI
- 10.3393/ac.2021.00696.0099
이용수
초록· 키워드
오류제보하기
Purpose: Bowel dysfunction commonly occurs in patients with locally advanced rectal cancer treated with a multimodal approach of chemoradiation therapy (CRT) combined with sphincter-preserving rectal resection. This study investigated the decline in anorectal function using sequential anorectal manometric measurements obtained before and after the multimodal treatment as well as at a 1-year follow-up.
Methods: This was a retrospective cohort study conducted in a single center. The study population consisted of patients with locally advanced mid- to low rectal cancer who received the preoperative CRT followed by sphincter-preserving surgery from 2012 to 2016. The anorectal manometric value measured after each treatment modality was compared to demonstrate the degree of decline in anorectal function. A generalized linear model of repeated measures was performed using the manometric values measured pre- and post-CRT, and at 12 months postoperatively.
Results: Overall, 100 patients with 3 consecutive manometric data were included in the final analysis. In the overall cohort study, the mean resting and maximal squeezing pressures showed insignificant decrement post-neoadjuvant CRT. At a 1-year postoperative follow-up, the maximal squeezing pressure significantly decreased. The maximal rectal sensory threshold demonstrated significant reduction consecutively after each following treatment (P<0.001).
Conclusion: The short-term effect of neoadjuvant CRT on the anal sphincters was relatively trivial. The following sphincter-saving surgery resulted in a profound disruption of the anorectal function. Patients with rectal cancer should be consulted on the consequence of multimodal treatment.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Change in anorectal function after standard rectal cancer treatment
대한임상종양학회 학술대회지
2019 .02
-
Usefulness of Anorectal Manometry for Diagnosing Continence Problems After a Low Anterior Resection
Annals of Coloproctology
2016 .01
-
Sphincter Saving Procedure for Anorectal Fistula
대한외과학회 학술대회 초록집
2019 .10
-
Matched case-control analysis comparing oncologic outcomes between preoperative and postoperative chemoradiotherapy for rectal cancer
Annals of Surgical Treatment and Research
2017 .04
-
Early and Late Functional Outcomes of Anal Sphincter-Sparing Procedures With Total Mesorectal Excision for Anorectal Adenocarcinoma
Annals of Coloproctology
2020 .01
-
Early Systemic Failure After Preoperative Chemoradiotherapy for the Treatment of Patients With Rectal Cancer
Annals of Coloproctology
2019 .01
-
Anorectal Manometric and Urodynamic Parameters According to the Spinal Cord Injury Lesion
Annals of Rehabilitation Medicine
2016 .01
-
Difference in Tumor Area as a Predictor of a Pathological Complete Response for Patients With Locally Advanced Rectal Cancer
Annals of Coloproctology
2017 .01
-
Clinical influence of neoadjuvant chemoradiotherapy on immunonutritional status in locally advanced rectal cancer
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2023 .06
-
New Perspectives on Predictive Biomarkers of Tumor Response and Their Clinical Application in Preoperative Chemoradiation Therapy for Rectal Cancer
Yonsei Medical Journal
2015 .01
-
Treatment Outcomes of Neoadjuvant Chemoradiation Therapy for Rectal Cancer Patients: A Nationwide Population-based Cohort Study in Korea
대한외과학회 학술대회 초록집
2020 .11
-
Outcomes of Preoperative Chemoradiotherapy and Combined Chemotherapy with Radiotherapy Without Surgery for Locally Advanced Rectal Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Effect of leukocyte alteration on treatment outcomes following preoperative chemoradiotherapy in patients with rectal cancer
Radiation oncology journal : ROJ
2017 .01
-
Impact of the type of Surgery And Preoperative Chemoradiotherapy On Bowel Function After Sphincter-Preserving Surgery for Rectal Cancer: A Single-Center Longitudinal Observational Study
대한외과학회 학술대회 초록집
2019 .10
-
Impact of Time Interval Between Chemoradiation and Surgery on Pathological Complete Response and Survival in Rectal Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Advances in surgery for locally advanced rectal cancer
Annals of Coloproctology
2022 .08
-
Long-term bowel functional outcomes following anal sphincter-preserving surgery for upper and middle rectal cancer: a single-center longitudinal study
Annals of Coloproctology
2024 .02
-
Anorectal malformation
대한외과학회 학술대회 초록집
2016 .11
-
Endoscopic Criteria for Evaluating Tumor Stage after Preoperative Chemoradiation Therapy in Locally Advanced Rectal Cancer
Cancer Research and Treatment
2016 .01
-
Postoperative Bowel Function After Anal Sphincter-Preserving Rectal Cancer Surgery: Risks Factors, Diagnostic Modalities, and Management
Annals of Coloproctology
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0