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논문 기본 정보

자료유형
학술저널
저자정보
Se-Ra Park (Department of Health Sciences and Technology GAIHST Gachon University) Myung Geun Kook (Department of Health Sciences and Technology GAIHST Gachon University) Soo-Rim Kim (Department of Health Sciences and Technology GAIHST Gachon University) Jin Woo Lee (Department of Health Sciences and Technology GAIHST Gachon University) Chan Hum Park (Hallym University) YunJae Jung (Department of Microbiology College of Medicine Gachon University) In-Sun Hong (Department of Health Sciences and Technology GAIHST Gachon University)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
946 - 968 (23page)
DOI
https://doi.org/10.1186/s40824-023-00376-9

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Background The endometrium, the inner lining of the uterine cavity, plays essential roles in embryo implantation and its subsequent development. Although some positive results were preliminarily archived, the regeneration of damaged endometrial tissues by administrating stem cells only is very challenging due to the lack of specific microenvironments and their low attachment rates at the sites of injury. In this context, various biomaterial-based scaffolds have been used to overcome these limitations by providing simple structural support for cell attachment. However, these scaffold-based strategies also cannot properly reflect patient tissue-specific structural complexity and thus show only limited therapeutic effects. Method Therefore, in the present study, we developed a customizable Lego-like multimodular endometrial tissue architecture by assembling individually fabricated tissue blocks. Results Each tissue block was fabricated by incorporating biodegradable biomaterials and certain endometrial constituent cells. Each small tissue block was effectively fabricated by integrating conventional mold casting and 3D printing techniques. The fabricated individual tissue blocks were properly assembled into a larger customized tissue architecture. This structure not only properly mimics the patient-specific multicellular microenvironment of the endometrial tissue but also properly responds to key reproductive hormones in a manner similar to the physiological functions. Conclusion This customizable modular tissue assembly allows easy and scalable configuration of a complex patient specific tissue microenvironment, thus accelerating various tissue regeneration procedures.

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