Association of Perceived Stress With Depression Among Vaccinated Healthcare Workers During the SARS-CoV-2 Variant Outbreak: The Mediating Role of Compassion Fatigue

Cai Xue; Li Guohong; Feng Haixia; Wang Xiaoyan; He Lijun; Luo Dan; Xu Cuirong; Huang Yingzi; Qiu Shanhu

doi:10.30773/pi.2022.0238

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자료유형: 학술저널

저자정보: Cai Xue (Department of Nursing Zhongda Hospital School of Medicine Southeast University Nanjing China) Li Guohong (Department of Nursing Zhongda Hospital School of Medicine Southeast University Nanjing China) Feng Haixia (Department of Nursing Zhongda Hospital School of Medicine Southeast University Nanjing China) Wang Xiaoyan (Department of Nursing Zhongda Hospital School of Medicine Southeast University Nanjing China) He Lijun (Department of Nursing Zhongda Hospital School of Medicine Southeast University Nanjing China) Luo Dan (Department of Nursing Zhongda Hospital School of Medicine Southeast University Nanjing China) Xu Cuirong (Department of Nursing Zhongda Hospital School of Medicine Southeast University Nanjing China) Huang Yingzi (Jiangsu Provincial Key Laboratory of Critical Care Medicine Department of Critical Care Medicine Zhongda Hospital School of Medicine Southeast University Nanjing China) Qiu Shanhu (Department of General Practice Zhongda Hospital School of Medicine Southeast University Nanjing China)

저널정보: 대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제20권 제4호

발행연도: 2023.4

수록면: 307 - 314 (8page)

DOI: 10.30773/pi.2022.0238

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Objective Depression was common during coronavirus disease-2019 (COVID-19) pandemic, while the association of perceived stress with depression among vaccinated healthcare workers has not been investigated. This study aimed to address this issue.Methods We included a total of 898 fully vaccinated healthcare workers during the outbreak of severe acute respiratory syndrome coronavirus 2 Delta variant in Nanjing, 2021. Depression was ascertained by Patient Health Questionnaire-9, with a cut-off score of ≥5 indicative of mild-to-severe depression. Perceived stress, resilience, and compassion fatigue were assessed by Perceived Stress Scale-10, Resilience Scale-25, and Professional Quality of Life Scale version-5, respectively. Logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI), along with subgroup and mediation analyses.Results The prevalence of mild-to-severe depression was 41.1% in vaccinated healthcare workers. The odd of mild-to-severe depression was increased with higher perceived stress. Compared with vaccinated healthcare workers with the lowest tertile of perceived stress, those with the highest tertile had increased odds of mild-to-severe depression by 120% (OR 2.20, 95% CI 1.46 to 3.31) after multivariable-adjustment. However, perceived stress was not associated with mild-to-severe depression in vaccinated healthcare workers with strong resilience, but was in those with weak resilience (p<sub>interaction</sub>=0.004). Further analysis showed that compassion fatigue mediated the relationship between perceived stress and mild-to-severe depression, with a mediating effect of 49.7%.Conclusion Perceived stress was related to an increased odd of mild-to-severe depression in vaccinated healthcare workers during COVID-19 pandemic, and this relationship might be explained by compassion fatigue.

#SARS-CoV-2 #Vaccination #Healthcare workers #Psychological stress #Depression.

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