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논문 기본 정보

자료유형
학술저널
저자정보
Christopher Traenka (Department of Neurology and Stroke Center University Hospital Basel University of Basel Basel Switzerland) Johannes Lorscheider (Department of Neurology and Stroke Center University Hospital Basel and University of Basel Basel Switzerland) Christian Hametner (Department of Neurology University Hospital Heidelberg Heidelberg Germany) Philipp Baumgartner (Division of Vascular Neurology and Neurorehabilitation Department of Neurology University Hospital of Zurich University of Zurich Zurich Switzerland) Jan Gralla (Institute of Diagnostic and Interventional Neuroradiology University Hospital Bern University of Bern Bern Switzerland) Mauro Magoni (ASST Spedali Civili Neurologia Vascolare Brescia Italy) Nicolas Martinez-Majander (Department of Neurology University Hospital Helsinki Helsinki Finland) Barbara Casolla (Univ. Lille Inserm CHU Lille U1172 - LilNCog - Lille Neuroscience & Cognition Lille France) Katharina Feil (Department of Neurology Ludwig Maximilian University (LMU) Munich Germany) Rosario Pascarella (Neurology Unit Arcispedale Santa Maria Nuova-IRCCS Reggio Emilia Italy) Panagiotis Papanagiotou (Department of Neurology Klinikum Bremen-Ost Bremen Germany) Annika Nordanstig (Department of Neurology Sahlgrenska University Hospital and Department of Clinical Neuroscience Institute for Neuroscience and Physiology Sahlgrenska Academy at University of Gothenburg Gothenburg Swe) Visnja Padjen (University of Belgrade Faculty of Medicine Neurology Clinic University Clinical Centre of Serbia Belgrade Serbia) Carlo W. Cereda (Stroke Center EOC Neurocenter of Southern Switzerland Lugano Switzerland) Marios Psychogios (Department of Neuroradiology Clinic of Radiology and Nuclear Medicine University Hospital Basel Basel Switzerland) Christian H. Nolte (Klinik für Neurologie mit experimenteller Neurologie Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin Humboldt-Universität zu Berlin Berlin Institute of Health Germany a) Andrea Zini (IRCCS Istituto delle Scienze Neurologiche di Bologna Department of Neurology and Stroke Center Maggiore Hospital Bologna Italy) Patrik Michel (Stroke Service Neurology Service Lausanne University Hospital Lausanne Switzerland) Yannick Béjot (Department of Neurology University Hospital Dijon Dijon France) Andreas Kastrup (Department of Neurology Klinikum Bremen-Ost Bremen Germany) Marialuisa Zedde (Neurology Unit Stroke Unit Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia Reggio Emilia Italy) Georg Kägi (Department of Neurology Kantonsspital St. Gallen St. Gallen Switzerland) Lars Kellert (Department of Neurology Ludwig Maximilian University (LMU) Munich Germany) Hilde Henon (Univ. Lille Inserm CHU Lille U1172 - LilNCog - Lille Neuroscience & Cognition Lille France) Sami Curtze (Neurology University of Helsinki and Helsinki University Hospital Helsinki Finland) Alessandro Pezzini (Department of Clinical and Experimental Sciences Neurology Clinic University of Brescia Brescia Italy) Marcel Arnold (Division of Vascular Neurology and Neurorehabilitation Department of Neurology University Hospital of Zurich University of Zurich Zurich Switzerland) Susanne Wegener (Division of Vascular Neurology and Neurorehabilitation Department of Neurology University Hospital of Zurich University of Zurich Zurich Switzerland) Peter Ringleb (Department of Neurology Heidelberg University Hospital Heidelberg Germany) Turgut Tatlisumak (Department of Neurology Sahlgrenska University Hospital and Department of Clinical Neuroscience Institute for Neuroscience and Physiology Sahlgrenska Academy at University of Gothenburg Gothenburg Swe) Paul J. Nederkoorn (Department of Neurology Amsterdam UMC location University of Amsterdam Amsterdam The Netherlands) Stefan T. Engelter (Department of Neurology and Stroke Center University Hospital Basel and University of Basel Basel Switzerland) Henrik Gensicke (Department of Neurology and Stroke Center University Hospital Basel and University of Basel Basel Switzerland)
저널정보
대한뇌졸중학회 대한뇌졸중학회지 대한뇌졸중영문학회지 제25권 제2호
발행연도
2023.5
수록면
272 - 281 (10page)
DOI
10.5853/jos.2022.03370

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Background and Purpose This study aimed to investigate the effect of endovascular treatment (EVT, with or without intravenous thrombolysis [IVT]) versus IVT alone on outcomes in patients with acute ischemic stroke (AIS) and intracranial large vessel occlusion (LVO) attributable to cervical artery dissection (CeAD).Methods This multinational cohort study was conducted based on prospectively collected data from the EVA-TRISP (EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients) collaboration. Consecutive patients (2015–2019) with AIS-LVO attributable to CeAD treated with EVT and/or IVT were included. Primary outcome measures were (1) favorable 3-month outcome (modified Rankin Scale score 0–2) and (2) complete recanalization (thrombolysis in cerebral infarction scale 2b/3). Odds ratios with 95% confidence intervals (OR [95% CI]) from logistic regression models were calculated (unadjusted, adjusted). Secondary analyses were performed in the patients with LVO in the anterior circulation (LVO<sub>ant</sub>) including propensity score matching.Results Among 290 patients, 222 (76.6%) had EVT and 68 (23.4%) IVT alone. EVT-treated patients had more severe strokes (National Institutes of Health Stroke Scale score, median [interquartile range]: 14 [10–19] vs. 4 [2–7], <i>P</i><0.001). The frequency of favorable 3-month outcome did not differ significantly between both groups (EVT: 64.0% vs. IVT: 86.8%; OR<sub>adjusted</sub> 0.56 [0.24–1.32]). EVT was associated with higher rates of recanalization (80.5% vs. 40.7%; OR<sub>adjusted</sub> 8.85 [4.28–18.29]) compared to IVT. All secondary analyses showed higher recanalization rates in the EVT-group, which however never translated into better functional outcome rates compared to the IVT-group.Conclusion We observed no signal of superiority of EVT over IVT regarding functional outcome in CeAD-patients with AIS and LVO despite higher rates of complete recanalization with EVT. Whether pathophysiological CeAD-characteristics or their younger age might explain this observation deserves further research.

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