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학술저널
저자정보
홍혜진 (이화여자대학교) 서채원 (이화여자대학교 뇌인지과학과 이화여자대학교 뇌융합과학연구원) Eun Namgung (Asan Medical Center Seoul) 하은지 (이화여자대학교) 이수지 (이화여자대학교) 김래영 (이화여자대학교) 송유미 (이화여자대학교) 오소현 (이화여자대학교) In Kyoon Lyoo (이화여자대학교) Hyeonseok Jeong (Department of Radiology Incheon St. Mary's Hospital The Catholic University of Korea) 윤수정 (이화여자대학교)
저널정보
한국뇌신경과학회 Experimental Neurobiology Experimental Neurobiology Vol.32 No.2
발행연도
2023.4
수록면
110 - 118 (9page)
DOI
10.5607/en23003

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Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder. Pain catastrophizing, characterized by magnification, rumination,and helplessness, increases perceived pain intensity and mental distress in CRPS patients. As functional connectivity patterns in CRPS remainlargely unknown, we aimed to investigate functional connectivity alterations in CRPS patients and their association with pain catastrophizing usinga whole-brain analysis approach. Twenty-one patients with CRPS and 49 healthy controls were included in the study for clinical assessment andresting-state functional magnetic resonance imaging. Between-group differences in whole-brain functional connectivity were examined througha Network-based Statistics analysis. Associations between altered functional connectivity and the extent of pain catastrophizing were also assessedin CRPS patients. Relative to healthy controls, CRPS patients showed higher levels of functional connectivity in the bilateral somatosensory subnetworks(components 1~2), but lower functional connectivity within the prefronto-posterior cingulate (component 3), prefrontal (component 4),prefronto-parietal (component 5), and thalamo-anterior cingulate (component 6) subnetworks (p<0.05, family-wise error corrected). Higher levelsof functional connectivity in components 1~2 (β=0.45, p=0.04) and lower levels of functional connectivity in components 3~6 (β=-0.49, p=0.047)were significantly correlated with higher levels of pain catastrophizing in CRPS patients. Higher functional connectivity in the somatosensorysubnetworks implicating exaggerated pain perception and lower functional connectivity in the prefronto-parieto-cingulo-thalamic subnetworksindicating impaired cognitive-affective pain processing may underlie pain catastrophizing in CRPS.

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