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논문 기본 정보

자료유형
학술저널
저자정보
이정민 (Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea.) Park Su Jin (Research Center, Honest Co., Ltd., 102 Maeyeo-ro, Dong-gu, Daegu 41064, Republic of Korea) 김유진 (Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea.) 김수영 (Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.) 장유나 (Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea.) 박아연 (Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea.) 호승현 (R&D Center, G&P Bioscience Co., Ltd., Seoul, Korea) Kim Dayoung (Research Laboratories, ILDONG Pharmaceutical Co., Ltd., Hwaseong, Korea.) 이정옥 (Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.) 유광호 (Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.) 김범준 (Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea.)
저널정보
대한피부과학회 Annals of Dermatology Annals of Dermatology Vol.36 No.1
발행연도
2024.2
수록면
18 - 28 (11page)
DOI
10.5021/ad.23.010

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Background: Actinidia polygama (silver vine) has been used in oriental medicine to treat gout, rheumatoid arthritis, and inflammation. Actinidia polygama water extract (APWE) is named PB203. Objective: To investigate whether PB203 has anti-photoaging effects and to understand the molecular mechanism underlying such effects. Methods: The antioxidant effect was assessed by 1,1-diphenyl-2-picr ylhydrazyl assay and 2′,7′-dichlorodihydrofluorescein diacetate staining in ultraviolet B (UVB)-irradiated HaCaT cells with or without PB203 treatment. Type I collagen, matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinase (TIMP-1), hyaluronic acid (HA), hyaluronan synthase 1 (HAS1) and HAS2 levels were measuring by enzyme-linked immunosorbent assay or reverse transcription quantitative polymerase chain reaction. Also, we investigate the effects of PB203 on wrinkle formation, and the potential mechanisms underlying such effects were investigated in UVB-induced wrinkle mouse model mice. Results: PB203 alleviated the UVB-induced reactive oxygen species production, phosphor ylation of JNK, ERK, and p38, and formation of AP-1. In addition, PB203 inhibited the decreases in type I collagen and TIMP-1 levels, and the increase in MMP-1 levels in UVB- exposed HaCaT cells. In UVB-induced wrinkle mouse model, PB203 inhibited the decreases in elastin and type I collagen levels as well as the increases in MMP-1 expression, wrinkle formation, and skin dehydration. Furthermore, PB203 increased the expression of filaggrin, HAS1, and HAS2, improving the skin barrier function. Conclusion: Taken together, we found that PB203 is as a potent candidate to ser ve as a functional ingredient or therapeutic agent to improve UVB-mediated skin aging.

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