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논문 기본 정보

자료유형
학술저널
저자정보
Kim Jie-Hyun (Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea) Jung Hwoon-Yong (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea) Yoo In Kyung (Division of Gastroenterology, Department of Internal Medicine, Cha Bundang Medical Center, Seongnam, Korea) Park Seon-Young (Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea) Kim Jae Gyu (Division of Gastroenterology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea) Sung Jae Kyu (Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea) Jang Jin Seok (Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea) Cheon Gab Jin (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea) Kim Kyoung Oh (Department of Gastroenterology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea) Kim Tae Oh (Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea) Lee Soo Teik (Division of Gastroenterology, Department of Internal Medicine, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Korea) Cho Kwang Bum (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea) Chun Hoon Jai (Department of Gastroenterology, Korea University Anam Hospital, Seoul, Korea) Park Jong-Jae (Department of Gastroenterology, Korea University Guro Hospital, Seoul, Korea) Park Moo In (Division of Gastroenterology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea) Jang Jae-Young (Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea) Jeon Seong Woo (Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea) Cho Jin Woong (Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea) Kang Dae Hwan (Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea) Kim Gwang Ha (Department of Internal Medicine, Pusan National University College of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea) Kim Jae J. (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea) Kim Sang Gyun (Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.) Kim Nayoung (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea) Lee Yong Chan (Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea) Hong Su Jin (Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea) Kim Hyun-Soo (Department of Internal Medicine, Wonju Severance Christian Hospital, Wonju, Korea) Lee Sora (Clinical R) Lee Sang Woo (Department of Gastroenterology, Korea University Ansan Hospital, Ansan, Korea)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver Vol.18 No.1
발행연도
2024.1
수록면
70 - 76 (7page)
DOI
10.5009/gnl220446

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Background/Aims: H2 receptor antagonists (H2RA) have been used to treat gastritis by inhibiting gastric acid. Proton pump inhibitors (PPIs) are more potent acid suppressants than H2RA. However, the efficacy and safety of low-dose PPI for treating gastritis remain unclear. The aim was to investigate the efficacy and safety of low-dose PPI for treating gastritis. Methods: A double-blind, noninferiority, multicenter, phase 3 clinical trial randomly assigned 476 patients with endoscopic erosive gastritis to a group using esomeprazole 10 mg (DW1903) daily and a group using famotidine 20 mg (DW1903R1) daily for 2 weeks. The full-analysis set included 319 patients (DW1903, n=159; DW1903R1, n=160) and the per-protocol set included 298 patients (DW1903, n=147; DW1903R1, n=151). The primary endpoint (erosion improvement rate) and secondary endpoint (erosion and edema cure rates, improvement rates of hemorrhage, erythema, and symptoms) were assessed after the treatment. Adverse events were compared. Results: According to the full-analysis set, the erosion improvement rates in the DW1903 and DW1903R1 groups were 59.8% and 58.8%, respectively. According to the per-protocol analysis, the erosion improvement rates in the DW1903 and DW1903R1 groups were 61.9% and 59.6%, respectively. Secondary endpoints were not significantly different between two groups except that the hemorrhagic improvement rate was higher in DW1903 with statistical tendency. The number of adverse events were not statistically different. Conclusions: DW1903 of a low-dose PPI was not inferior to DW1903R1 of H2RA. Thus, low-dose PPI can be a novel option for treating gastritis (ClinicalTrials.gov Identifier: NCT05163756).
#Gastritis #Phase III clinical trial #Proton pump inhibitors #Histamine H2 antagonists

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