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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.9
- 수록면
- 169 - 172 (4page)
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Asthma is a chronic lung disease characterized by wheezing, cough, and chest pain. The objective of this study was to examine asthmatic effect due to house dust mite (HDM) according to age and exposure duration. Asthma induction in young (6 weeks) and old (12 months) aged C57BL6/J mice was accomplished by HDM administration. Bronchoalveolar lavage fluid (BALF) was collected. Inflammatory cells in BALF were counted. Mucus production in lung tissues was evaluated by periodic acid Schiff (PAS) staining. Intraperitoneal (i.p.) and intranasal (IN) injection of HDM induced infiltration of inflammatory cells into lungs of mice. The increase of total cells was higher in young mice than in old mice. Mucus secretion from goblet cells increased after HDM administration, with young mice showing higher mucus production than old mice. In chronic asthmatic state induced by i.p. and IN (three times) injection, old mice exhibited more inflammatory cells, specifically eosinophils, and mucus production than young mice. Our findings suggest that age and exposure duration are critical factors in different manifestations of asthma. Thus, they should be overarchingly considered in drug development for asthma.
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