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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 101 - 101 (1page)
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Background: Allergic asthma is a chronic inflammatory lung disease caused by a T helper 2 cell-mediated allergic response and lung inflammation and remodeling through oxidative stress. 6-shogaol and 6-gingerol, naturally derived compounds of ginger (Zingiber officinale Roscoe), has an anti-allergic effect on allergic rhinitis in mouse models.
Purpose: The aim of this study is to demonstrate the anti-allergic effect and anti-inflammatory effect of 6-shogaol and 6-gingerol in an ovalbumin (OVA)-induced asthma mouse model (in vitro) and in vivo.
Methods: To establish the asthma mouse model, BALB/c mice were sensitized and challenged with OVA and alum. Lung lobes and BALF were used to investigate the effect of 6-shogaol and 6-gingerol in asthma mouse model. In addition, mast cell degranulation was assessed by antigen stimulated RBL-2H3 cell line. Jurkat cell viability was determined to confirm cell cytotoxicity of 6-g ... 전체 초록 보기
Purpose: The aim of this study is to demonstrate the anti-allergic effect and anti-inflammatory effect of 6-shogaol and 6-gingerol in an ovalbumin (OVA)-induced asthma mouse model (in vitro) and in vivo.
Methods: To establish the asthma mouse model, BALB/c mice were sensitized and challenged with OVA and alum. Lung lobes and BALF were used to investigate the effect of 6-shogaol and 6-gingerol in asthma mouse model. In addition, mast cell degranulation was assessed by antigen stimulated RBL-2H3 cell line. Jurkat cell viability was determined to confirm cell cytotoxicity of 6-g ... 전체 초록 보기
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