지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.9
- 수록면
- 220 - 226 (7page)
- DOI
- 10.20307/nps.2024.30.3.220
이용수
초록· 키워드
오류제보하기
Vitiligo is a type of chronic autoimmune skin disorder that is highly unpredictable. Houttuynia cordata Thunb. (HC) is a natural compound with several pharmacological properties; however, the fundamental mechanisms of HC effects on Vitiligo have yet to be fully understood. This study aimed to evaluate the effects of HC on the oxidative injury of melanocytes in vivo and in vitro. This study demonstrated that compounds significantly prevented the hydrogen peroxide (H₂O₂)-induced B16F10 cell loss of viability and melanin synthesis; in addition, cell apoptosis-regulating of melanocytes significantly decreased, and the expression level of TRP-1 and MITF increased dose-dependently. In animal experiments, C57BL/6 mice received 5% hydroquinone (HQ) for 5 weeks and were treated with HC for 2 weeks. HQ-stimulated vitiligo in mice also produced melanocyte and melanosome degradation. The melanin content and tyrosinase activity of the mice (skin) that received the HC group significantly increased compared to the untreated and 8-methoxyprosalen (8-MOP) groups. These experiments suggest that the HC has potential protectivea nd therapeutic effects for vitiligo.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
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